Sodium nitroprusside

Sodium nitroprusside
Molecular structure of this compound (top), and a picture of a sample (bottom).
Clinical data
Trade namesNipride, Nitropress, others
Other namesSNP
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: C
Routes of
administration
Intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability100% (intravenous)
MetabolismBy haemoglobin being converted to cyanmethaemoglobin and cyanide ions
Onset of actionnearly immediate[3]
Elimination half-life<2 minutes (3 days for thiocyanate metabolite)
Duration of action1 to 10 minutes[3]
Excretionkidney (100%; as thiocyanate)[4]
Identifiers
  • Sodium pentacyanidonitrosylferrate(III)
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.119.126 Edit this at Wikidata
Chemical and physical data
FormulaC5FeN6Na2O
Molar mass261.921 g·mol−1
3D model (JSmol)
Density1.72 g/cm3
Solubility in water100 mg/mL (20 °C)
  • [Na+].[Na+].O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N
  • InChI=1S/5CN.Fe.NO.2Na/c5*1-2;;1-2;;/q;;;;;2*-1;2*+1
  • Key:FPWUWQVZUNFZQM-UHFFFAOYSA-N

Sodium nitroprusside (SNP), sold under the brand name Nitropress among others, is a medication used to lower blood pressure.[3] This may be done if the blood pressure is very high and resulting in symptoms, in certain types of heart failure, and during surgery to decrease bleeding.[3] It is used by continuous injection into a vein.[3] Onset is nearly immediate and effects last for up to ten minutes.[3]

It is available as a generic medication.[5]

  1. ^ "Nitroprusside Rmb, Nitroprusside Sxp, Nitroprusside Tlb (Southern XP IP Pty Ltd)". Therapeutic Goods Administration (TGA). 5 December 2022. Retrieved 9 April 2023.
  2. ^ "Sodium nitroprusside Baxter (Baxter Healthcare Pty Ltd)". Therapeutic Goods Administration (TGA). 2 June 2023. Retrieved 10 September 2023.
  3. ^ a b c d e f "Sodium Nitroprusside". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
  4. ^ Cite error: The named reference GG was invoked but never defined (see the help page).
  5. ^ "First Generic Drug Approvals". U.S. Food and Drug Administration. 17 October 2022. Retrieved 28 November 2022.