Sodium zirconium cyclosilicate

Sodium zirconium cyclosilicate
Crystal structure of ZS-9. Blue spheres  =  oxygen atoms, red spheres  =  zirconium atoms, green spheres  =  silicon atoms.
Clinical data
Trade namesLokelma
Other namesZS-9
AHFS/Drugs.comMonograph
MedlinePlusa618035
License data
Pregnancy
category
Routes of
administration
By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityNot absorbed
ExcretionFeces
Identifiers
  • Silicic acid, sodium zirconium(4+) salt (3:2:1), hydrate
CAS Number
DrugBank
UNII
KEGG
Chemical and physical data
Formula(2Na·H2O·3H4SiO4·H4ZrO6)n

Sodium zirconium cyclosilicate, sold under the brand name Lokelma, is a medication used to treat high blood potassium.[5] Onset of effects occurs in one to six hours.[5] It is taken by mouth.[5]

Common side effects include swelling and low blood potassium.[5] Use is likely safe in pregnancy and breastfeeding.[5] It works by binding potassium ions in the gastrointestinal tract which is then lost in the stool.[5][6]

Sodium zirconium cyclosilicate was approved for medical use in the European Union and in the United States in 2018.[5][4][7] It was developed by AstraZeneca.[5]

  1. ^ a b "Lokelma APMDS". Therapeutic Goods Administration (TGA). 24 May 2024. Retrieved 10 June 2024.
  2. ^ "Summary Basis of Decision (SBD) for Lokelma". Health Canada. 23 October 2014. Archived from the original on 31 May 2022. Retrieved 29 May 2022.
  3. ^ "Lokelma- sodium zirconium cyclosilicate powder, for suspension". DailyMed. 30 September 2022. Archived from the original on 5 December 2022. Retrieved 27 February 2023.
  4. ^ a b "Lokelma EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 8 January 2021. Retrieved 11 October 2019.
  5. ^ a b c d e f g h "Sodium Zirconium Cyclosilicate Monograph for Professionals". Drugs.com. Archived from the original on 1 August 2020. Retrieved 11 October 2019.
  6. ^ Hoy SM (October 2018). "Sodium Zirconium Cyclosilicate: A Review in Hyperkalaemia". Drugs. 78 (15): 1605–1613. doi:10.1007/s40265-018-0991-6. PMC 6433811. PMID 30306338.
  7. ^ "Drug Approval Package: Lokelma (sodium zirconium cyclosilicate)". U.S. Food and Drug Administration (FDA). 8 June 2018. Archived from the original on 13 April 2021. Retrieved 7 May 2020.