Solenoid protein domain

Common examples of protein domains with a solenoid architecture: the WD40 repeat domain of beta-TrCP (green), leucine-rich repeat domain of TLR2 (red), armadillo repeat domain of beta-catenin (blue), ankyrin repeat domain of ANKRA2 (orange), kelch repeat domain of Keap1 (yellow) and HEAT repeat domain of a PP2A regulatory subunit R1a (magenta).

Solenoid protein domains are a highly modular type of protein domain. They consist of a chain of nearly identical folds, often simply called tandem repeats. They are extremely common among all types of proteins, though exact figures are unknown.[1]

  1. ^ Andrade MA, Perez-Iratxeta C, Ponting CP (2001). "Protein repeats: structures, functions, and evolution". J. Struct. Biol. 134 (2–3): 117–31. doi:10.1006/jsbi.2001.4392. PMID 11551174.