Sorivudine

Sorivudine
Clinical data
Trade names	Usevir, Brovavir
Other names	BV-araU, Bromovinyl araU, 5-Bromovinyl-araU, 5-[(E)-2-bromoethenyl]-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Routes of; administration	Oral
ATC code	none;
Pharmacokinetic data
Metabolism	Viral thymidine kinase
Excretion	Kidney
Identifiers
	IUPAC name 1-β-D-arabinofuranosyl-5-[(E)-2-bromovinyl]pyrimidine-2,4(1H,3H)-dione;
CAS Number	77181-69-2 ;
PubChem CID	5282192;
ChemSpider	4445384 ;
UNII	C7VOZ162LV;
KEGG	D01734 ;
ChEMBL	ChEMBL375035 ;
CompTox Dashboard (EPA)	DTXSID6057827 ;
Chemical and physical data
Formula	C11H13BrN2O6
Molar mass	349.137 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1c(c(=O)[nH]c(=O)n1[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O)/C=C/Br;
	InChI InChI=1S/C11H13BrN2O6/c12-2-1-5-3-14(11(19)13-9(5)18)10-8(17)7(16)6(4-15)20-10/h1-3,6-8,10,15-17H,4H2,(H,13,18,19)/b2-1+/t6-,7-,8+,10-/m1/s1 ; Key:GCQYYIHYQMVWLT-HQNLTJAPSA-N ;
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Sorivudine (INN), is a nucleoside analogue antiviral drug, marketed under trade names such as Usevir (Nippon Shoji, Eisai) and Brovavir (BMS). It is used for the treatment of varicella zoster virus infections.^[1]

^ Whitley RJ (1996). "Sorivudine: A Potent Inhibitor of Varicella Zoster Virus Replication". Antiviral Chemotherapy 4. Advances in Experimental Medicine and Biology. Vol. 394. pp. 41–4. doi:10.1007/978-1-4757-9209-6_5. ISBN 978-1-4757-9211-9. PMID 8815706.