Sortase A (EC 3.4.22.70 , SrtA , SrtA protein , SrtA sortase ) is an enzyme .[ 1] [ 2] [ 3] cell wall sorting reaction, in which a surface protein with a sorting signal containing a LPXTG motif, is cleaved between the Thr and Gly residue.
This enzyme belongs to the peptidase family C60.
^ Ton-That H, Liu G, Mazmanian SK, Faull KF, Schneewind O (October 1999). "Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif" . Proceedings of the National Academy of Sciences of the United States of America . 96 (22): 12424–9. Bibcode :1999PNAS...9612424T . doi :10.1073/pnas.96.22.12424 PMC 22937 PMID 10535938 . ^ Zong Y, Bice TW, Ton-That H, Schneewind O, Narayana SV (July 2004). "Crystal structures of Staphylococcus aureus sortase A and its substrate complex" . The Journal of Biological Chemistry . 279 (30): 31383–9. doi :10.1074/jbc.m401374200 PMID 15117963 . ^ Race PR, Bentley ML, Melvin JA, Crow A, Hughes RK, Smith WD, Sessions RB, Kehoe MA, McCafferty DG, Banfield MJ (March 2009). "Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism" . The Journal of Biological Chemistry . 284 (11): 6924–33. doi :10.1074/jbc.m805406200 PMC 2652338 PMID 19129180 .