| PX domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | PX | ||||||||
| Pfam | PF00787 | ||||||||
| InterPro | IPR001683 | ||||||||
| SMART | PX | ||||||||
| PROSITE | PDOC50195 | ||||||||
| SCOP2 | 1h6h / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 57 | ||||||||
| OPM protein | 4on3 | ||||||||
| |||||||||
| Sorting nexin, N-terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Sorting_nexin | ||||||||
| Pfam | PF03700 | ||||||||
| InterPro | IPR005329 | ||||||||
| |||||||||
| Vps5 C terminal like (BAR domain) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Vps5 | ||||||||
| Pfam | PF09325 | ||||||||
| InterPro | IPR015404 | ||||||||
| |||||||||
| Sorting nexin, C terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Nexin_C | ||||||||
| Pfam | PF08628 | ||||||||
| InterPro | IPR013937 | ||||||||
| |||||||||
| WASP-binding domain of Sorting nexin protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | BAR3-WASP | ||||||||
| Pfam | PF10456 | ||||||||
| |||||||||
Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain (a phospholipid-binding motif) or through protein–protein interactions with membrane-associated protein complexes[2][3] Some members of this family have been shown to facilitate protein sorting.
- ^ Bravo J, Karathanassis D, Pacold CM, et al. (October 2001). "The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate". Mol. Cell. 8 (4): 829–39. doi:10.1016/S1097-2765(01)00372-0. PMID 11684018.
- ^ Dixon JE, Worby CA (2002). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–931. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
- ^ Worby CA, Dixon JE (2002). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.