Sosibius (Ancient Greek: Σωσίβιoς; floruit 221-204 BC) was the chief minister of Ptolemy IV Philopator (221–204 BC), king of Egypt. Nothing is known of his origin or parentage, though he may have been a son of Sosibius of Tarentum; nor is there any account of how he rose to power. He is first attested immediately after the accession of Ptolemy IV in 221 BC, exercising great influence over the 22-year old king alongside Agathocles, the brother of Ptolemy IV's mistress Agathoclea. He remained a major force throughout the reign and helped ensure the smooth succession of Ptolemy V Epiphanes in 204 BC. After that he disappears from the record.