Sotalol

Sotalol
Clinical data
Trade namesBetapace, Sorine, Sotylize, others[1]
AHFS/Drugs.comMonograph
MedlinePlusa693010
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
Drug classBeta blocker
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability90–100%[3]
MetabolismNot metabolized[3]
Elimination half-life12 hours[3]
ExcretionKidney
Mammary gland (In lactating individuals)[3]
Identifiers
  • (RS)-N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H20N2O3S
Molar mass272.36 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • O=S(=O)(Nc1ccc(cc1)C(O)CNC(C)C)C
  • InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 checkY
  • Key:ZBMZVLHSJCTVON-UHFFFAOYSA-N checkY
  (verify)

Sotalol, sold under the brand name Betapace among others, is a medication used to treat and prevent abnormal heart rhythms.[1] Evidence does not support a decreased risk of death with long term use.[1] It is taken by mouth or given by injection into a vein.[1]

Common side effects include a slow heart rate, chest pain, low blood pressure, feeling tired, dizziness, shortness of breath, problems seeing, vomiting, and swelling.[1] Other serious side effects may include QT prolongation, heart failure, or bronchospasm.[4] Sotalol is a non-selective β-adrenergic receptor blocker which has both class II and class III antiarrhythmic properties.[1]

Sotalol was first described in 1964 and came into medical use in 1974.[5] It is available as a generic medication.[4] In 2020, it was the 296th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[6][7]

  1. ^ a b c d e f "Sotalol Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 18 March 2019.
  2. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  3. ^ a b c d Cite error: The named reference fda2009 was invoked but never defined (see the help page).
  4. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 108. ISBN 9780857113382.
  5. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 460. ISBN 9783527607495.
  6. ^ "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
  7. ^ "Sotalol - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.