Specific rotation

Recording optical rotation with a polarimeter: The plane of polarisation of plane polarised light (4) rotates (6) as it passes through an optically active sample (5). This angle is determined with a rotatable polarizing filter (7).

In chemistry, specific rotation ([α]) is a property of a chiral chemical compound.[1]: 244  It is defined as the change in orientation of monochromatic plane-polarized light, per unit distance–concentration product, as the light passes through a sample of a compound in solution.[2]: 2–65  Compounds which rotate the plane of polarization of a beam of plane polarized light clockwise are said to be dextrorotary, and correspond with positive specific rotation values, while compounds which rotate the plane of polarization of plane polarized light counterclockwise are said to be levorotary, and correspond with negative values.[1]: 245  If a compound is able to rotate the plane of polarization of plane-polarized light, it is said to be “optically active”.

Specific rotation is an intensive property, distinguishing it from the more general phenomenon of optical rotation. As such, the observed rotation (α) of a sample of a compound can be used to quantify the enantiomeric excess of that compound, provided that the specific rotation ([α]) for the enantiopure compound is known. The variance of specific rotation with wavelength—a phenomenon known as optical rotatory dispersion—can be used to find the absolute configuration of a molecule.[3]: 124  The concentration of bulk sugar solutions is sometimes determined by comparison of the observed optical rotation with the known specific rotation.

  1. ^ a b Cite error: The named reference vogelPractical was invoked but never defined (see the help page).
  2. ^ Cite error: The named reference crc95 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference sundberg was invoked but never defined (see the help page).