Spectinomycin

Spectinomycin
Clinical data
Trade namesTrobicin
Other names(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one , SPT/SPE/SC/SP[1]
AHFS/Drugs.comMonograph
Routes of
administration		IM
ATC code
Legal status
Legal status
  • US: not available
Identifiers
  • (1R,3S,5R,8R,10S,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.03,8]tetradecan-7-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.015.374 Edit this at Wikidata
Chemical and physical data
FormulaC14H24N2O7
Molar mass332.353 g·mol−1
3D model (JSmol)
Melting point184 to 194 °C (363 to 381 °F)
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  • InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3/t5-,7-,8+,9+,10+,11-,12-,13+,14+/m1/s1 checkY
  • Key:UNFWWIHTNXNPBV-WXKVUWSESA-N checkY
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Spectinomycin, sold under the tradename Trobicin among others, is an antibiotic useful for the treatment of gonorrhea infections.[2] It is given by injection into a muscle.[2]

Common side effects include pain at the area of injection, rash, nausea, fever, and trouble sleeping.[2] Severe allergic reactions may occasionally occur.[2] It is generally safe to use during pregnancy.[2] It may be used by those who are allergic to penicillin or cephalosporins.[2] It is in the aminocyclitol class of drugs and works by stopping the making of protein by certain bacteria.[2]

Spectinomycin was discovered in 1961.[3] It is on the World Health Organization's List of Essential Medicines.[4] It is not available in the United States for human use.[2] It is made from the bacterium Streptomyces spectabilis.[2]

  1. ^ "Antibiotic abbreviations list". Retrieved 22 June 2023.
  2. ^ a b c d e f g h i "Spectinomycin Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 2015-09-24. Retrieved Sep 6, 2015.
  3. ^ Textbook of Drug Design and Discovery, Fourth Edition. CRC Press. 2009. p. 438. ISBN 9781439882405. Archived from the original on 2015-10-03.
  4. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.