Squalene monooxygenase

SQLE
Identifiers
Aliases	SQLE, entrez:6713, squalene epoxidase
External IDs	OMIM: 602019; MGI: 109296; HomoloGene: 2355; GeneCards: SQLE; OMA:SQLE - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	125,022,283 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	59,203,041 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gingival epithelium; ; bronchial epithelial cell; ; cartilage tissue; ; nipple; ; C1 segment; ; inferior ganglion of vagus nerve; ; tibia; ; human penis;
	Top expressed in
	genital tubercle; ; hair follicle; ; ciliary body; ; corneal stroma; ; trigeminal ganglion; ; iris; ; choroid plexus of fourth ventricle; ; lip; ; ventricular zone; ; anterior horn of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; flavin adenine dinucleotide binding; squalene monooxygenase activity; FAD binding;
Cellular component	organelle membrane; integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	cellular aromatic compound metabolic process; cholesterol biosynthetic process; response to organic substance; cholesterol metabolic process; sterol biosynthetic process; regulation of cholesterol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	6713
	20775
	ENSG00000104549
	ENSMUSG00000022351
	Q14534
	P52019
	NM_003129
	NM_009270
	NP_003120
	NP_033296
	Wikidata
View/Edit Human	View/Edit Mouse

Search
PMC	articles
PubMed	articles
NCBI	proteins

Squalene epoxidase
Squalene epoxidase
	Chemical reaction catalyzed by squalene epoxidase.
Identifiers
EC no.	1.14.13.132
CAS no.	9029-62-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Squalene monooxygenase (also called squalene epoxidase) is a eukaryotic enzyme that uses NADPH and diatomic oxygen to oxidize squalene to 2,3-oxidosqualene (squalene epoxide). Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.^[5] In humans, squalene epoxidase is encoded by the SQLE gene.^[6] Several eukaryote genomes lack a squalene monooxygenase encoding gene, but instead encode an alternative squalene epoxidase that performs the same task.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104549 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022351 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SQLE squalene epoxidase".
^ Nagai M, Sakakibara J, Wakui K, Fukushima Y, Igarashi S, Tsuji S, Arakawa M, Ono T (Aug 1997). "Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1". Genomics. 44 (1): 141–3. doi:10.1006/geno.1997.4825. PMID 9286711.
^ Pollier J, Vancaester E, Kuzhiumparambil U, Vickers CE, Vandepoele K, Goossens A, Fabris M (2019). "A widespread alternative squalene epoxidase participates in eukaryote steroid biosynthesis". Nature Microbiology. 4 (2): 226–233. doi:10.1038/s41564-018-0305-5. hdl:1854/LU-8587985. PMID 30478288. S2CID 53726187.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104549 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022351 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez_6713-5] "Entrez Gene: SQLE squalene epoxidase".

[pmid9286711-6] Nagai M, Sakakibara J, Wakui K, Fukushima Y, Igarashi S, Tsuji S, Arakawa M, Ono T (Aug 1997). "Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1". Genomics. 44 (1): 141–3. doi:10.1006/geno.1997.4825. PMID 9286711.

[pmid30478288-7] Pollier J, Vancaester E, Kuzhiumparambil U, Vickers CE, Vandepoele K, Goossens A, Fabris M (2019). "A widespread alternative squalene epoxidase participates in eukaryote steroid biosynthesis". Nature Microbiology. 4 (2): 226–233. doi:10.1038/s41564-018-0305-5. hdl:1854/LU-8587985. PMID 30478288. S2CID 53726187.

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