Staufen (protein)

Maternal effect protein staufen
Identifiers
OrganismDrosophila melanogaster
Symbolstau
UniProtP25159
Search for
StructuresSwiss-model
DomainsInterPro

Staufen is a protein product of a maternally expressed gene first identified in Drosophila melanogaster. The protein has been implicated in helping regulate genes important in determination of gradients that set up the anterior posterior axis such as bicoid and oskar. Staufen proteins, abbreviated Stau, are necessary for cell localization during the oogenesis and zygotic development.[1] It is involved in targeting of the messenger RNA encoding these genes to the correct pole of the egg cell.[2][3]

Human homologs of this protein include STAU1 and STAU2.

  1. ^ "Society for Developmental Biology | Home". www.sdbonline.org. Retrieved 2022-05-03.
  2. ^ Martin KC, Ephrussi A (February 2009). "mRNA Localization: Gene Expression in the Spatial Dimension". Cell. 136 (4): 719–30. doi:10.1016/j.cell.2009.01.044. PMC 2819924. PMID 19239891.
  3. ^ Houchmandzadeh B, Wieschaus E, Leibler S (February 2002). "Establishment of developmental precision and proportions in the early Drosophila embryo". Nature. 415 (6873): 798–802. Bibcode:2002Natur.415..798H. doi:10.1038/415798a. PMID 11845210. S2CID 4386630.