| Steatohepatitis | |
|---|---|
 | |
| Micrograph of steatohepatitis. Liver biopsy using trichrome stain | |
| Specialty | Gastroenterology  |
Steatohepatitis is a type of fatty liver disease, characterized by inflammation of the liver with concurrent fat accumulation in liver. Mere deposition of fat in the liver is termed steatosis, and together these constitute fatty liver changes.[1]
There are 2 main types of fatty liver disease (FLD):
- Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) (previously non-alcoholic fatty liver disease or NAFLD)
- Alcohol-associated (Alcohol-related) Liver Disease (ALD)
Risk factors for MASLD include diabetes, obesity and metabolic syndrome. When inflammation is present it is referred to as alcoholic steatohepatitis and nonalcoholic (metabolic dysfunction associated) steatohepatitis (MASH, previously NASH).[2] Steatohepatitis of either cause may progress to cirrhosis, and MASH is now believed to be a frequent cause of unexplained cirrhosis (at least in Western societies). MASH is also associated with lysosomal acid lipase deficiency.[medical citation needed]
The word is from steato-, meaning "fat" and hepatitis, meaning "inflammation of the liver".
- ^ "Alcoholic Steatohepatitis – Causes, Symptoms And Treatment". Doctor Tipster. 8 July 2011. Retrieved 21 Dec 2016.
- ^ Vuppalanchi R, Chalasani N (January 2009). "Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management". Hepatology. 49 (1): 306–317. doi:10.1002/hep.22603. PMC 2766096. PMID 19065650.