Stem cell factor

KITLG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EXZ, 1SCF, 2E9W
Identifiers
Aliases	KITLG, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, DCUA, KIT ligand, DFNA69, SLF
External IDs	OMIM: 184745; MGI: 96974; HomoloGene: 692; GeneCards: KITLG; OMA:KITLG - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.32 Start 88,492,793 bp[1] End 88,580,851 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D1|10 51.4 cM Start 99,851,492 bp[2] End 99,936,278 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura cardia lower lobe of lung pylorus lateral nuclear group of thalamus middle temporal gyrus parietal pleura endothelial cell skin of hip seminal vesicula Top expressed in habenula left lung lobe medial geniculate nucleus medial dorsal nucleus lateral geniculate nucleus lobe of cerebellum dermis cerebellar vermis cardiac muscle tissue of left ventricle right lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function stem cell factor receptor binding protein binding growth factor activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity cytokine activity Cellular component integral component of membrane membrane extracellular region cytoskeleton cell projection filopodium lamellipodium cytoplasm plasma membrane extracellular space Biological process male gonad development MAPK cascade cell adhesion embryonic hemopoiesis cell population proliferation signal transduction phosphatidylinositol phosphate biosynthetic process regulation of signaling receptor activity positive regulation of protein kinase B signaling positive regulation of cell population proliferation ovarian follicle development neural crest cell migration positive regulation of leukocyte migration positive regulation of myeloid leukocyte differentiation negative regulation of mast cell apoptotic process ectopic germ cell programmed cell death negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of melanocyte differentiation positive regulation of Ras protein signal transduction positive regulation of peptidyl-tyrosine phosphorylation positive regulation of mast cell proliferation extrinsic apoptotic signaling pathway in absence of ligand positive regulation of hematopoietic stem cell proliferation positive regulation of hematopoietic progenitor cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4254 17311 Ensembl ENSG00000049130 ENSMUSG00000019966 UniProt P21583 P20826 RefSeq (mRNA) NM_003994 NM_000899 NM_013598 NM_001347156 RefSeq (protein) NP_000890 NP_003985 NP_001334085 NP_038626 Location (UCSC) Chr 12: 88.49 – 88.58 Mb Chr 10: 99.85 – 99.94 Mb PubMed search [3] [4]
Wikidata
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Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis.