Sterol O-acyltransferase

sterol O-acyltransferase
Identifiers
EC no.2.3.1.26
CAS no.9027-63-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
sterol O-acyltransferase 1
Identifiers
SymbolSOAT1
Alt. symbolsACAT, SOAT, STAT
NCBI gene6646
HGNC11177
OMIM102642
RefSeqNM_003101
UniProtP35610
Other data
EC number2.3.1.26
LocusChr. 1 q25
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StructuresSwiss-model
DomainsInterPro
sterol O-acyltransferase 2
Identifiers
SymbolSOAT2
Alt. symbolsACAT2
NCBI gene8435
HGNC11178
OMIM601311
RefSeqNM_003578
UniProtO75908
Other data
EC number2.3.1.26
LocusChr. 12 [1]
Search for
StructuresSwiss-model
DomainsInterPro

Sterol O-acyltransferase (also called Acyl-CoA cholesterol acyltransferase, Acyl-CoA cholesterin acyltransferase[citation needed] or simply ACAT) is an intracellular protein located in the endoplasmic reticulum that forms cholesteryl esters from cholesterol.

Sterol O-acyltransferase catalyzes the chemical reaction:

acyl-CoA + cholesterol CoA + cholesterol ester

Thus, the two substrates of this enzyme are acyl-CoA and cholesterol, whereas its two products are CoA and cholesteryl ester.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups, the membrane-bound O-acyltransferases. This enzyme participates in bile acid biosynthesis.