Stichodactyla toxin

ShK domain-like
Rainbow colored cartoon diagram (N-terminus = blue, C-terminus = red) of an NMR solution structure of the ShK toxin.[1] Sidechains of cysteine residues involved in disulfide linkages are displayed as sticks and the sulfur atoms in these links are colored yellow.
Identifiers
SymbolShK
PfamPF01549
InterProIPR003582
SMARTSM00254
SCOP21roo / SCOPe / SUPFAM
TCDB8.B.14
OPM superfamily296
OPM protein2lg4
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Kappa-stichotoxin-She3a
Identifiers
OrganismStichodactyla helianthus
Symbol?
UniProtP29187
Search for
StructuresSwiss-model
DomainsInterPro

Stichodactyla toxin (ShK, ShkT) is a 35-residue basic peptide from the sea anemone Stichodactyla helianthus that blocks a number of potassium channels. Related peptides form a conserved family of protein domains known as the ShkT domain. Another well-studied toxin of the family is BgK from Bunodosoma granulifera.

An analogue of ShK called ShK-186 or Dalazatide is in human trials as a therapeutic for autoimmune diseases.

  1. ^ PDB: 1ROO​; Tudor JE, Pallaghy PK, Pennington MW, Norton RS (April 1996). "Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone". Nature Structural Biology. 3 (4): 317–20. doi:10.1038/nsb0496-317. PMID 8599755. S2CID 9180663.