Strabismus (protein)

vang-like 1 (van gogh, Drosophila)
Identifiers
SymbolVANGL1
NCBI gene81839
OMIM610132

Strabismus was originally identified as a Drosophila protein involved in planar cell polarity.[1] Flies with mutated strabismus genes have altered development of ommatidia in their eyes. Vertebrates have two Strabismus-related proteins, VANGL1 and VANGL2 (an alternate name for the Drosophila "Strabismus" protein is "Van Gogh").

The amino acid sequence and localization studies for Strabismus indicate that it is a membrane protein. Prickle is another protein in the planar cell polarity signaling pathway. Prickle is recruited to the cell surface membrane by strabismus.[2] In cells of the developing Drosophila wing, Prickle and Strabismus are concentrated at the cell surface membrane on the most proximal side of cells.[3]

  1. ^ Wolff T, Rubin GM (March 1998). "Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila". Development. 125 (6): 1149–59. doi:10.1242/dev.125.6.1149. PMID 9463361.
  2. ^ Bastock R, Strutt H, Strutt D (July 2003). "Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning". Development. 130 (13): 3007–14. doi:10.1242/dev.00526. PMID 12756182.
  3. ^ Fanto M, McNeill H (February 2004). "Planar polarity from flies to vertebrates". J. Cell Sci. 117 (Pt 4): 527–33. doi:10.1242/jcs.00973. PMID 14730010.