 Complex of catalytic domain of human plasmin and streptokinase | |
| Clinical data | |
|---|---|
| Other names | SK |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Routes of administration | Intravenous |
| ATC code | |
| Identifiers | |
| CAS Number | |
| DrugBank | |
| ChemSpider |
|
| UNII | |
| ECHA InfoCard | 100.029.667 |
| Chemical and physical data | |
| Formula | C2100H3278N566O669S4 |
| Molar mass | 47286.86 g·mol−1 |
Streptokinase is a thrombolytic medication activating plasminogen by nonenzymatic mechanism.[1] As a medication it is used to break down clots in some cases of myocardial infarction (heart attack), pulmonary embolism, and arterial thromboembolism.[2] The type of heart attack it is used in is an ST elevation myocardial infarction (STEMI).[3] It is given by injection into a vein.[2]
Side effects include nausea, bleeding, low blood pressure, and allergic reactions.[2] A second use in a person's lifetime is not recommended.[2] While no harm has been found with use in pregnancy, it has not been well studied in this group.[4] Streptokinase is in the antithrombotic family of medications and works by turning on the fibrinolytic system.[3]
Streptokinase was discovered in 1933 from beta-hemolytic streptococci.[5] It is on the World Health Organization's List of Essential Medicines.[6] It is no longer commercially available in the United States.[7]
- ^ Mican J, Toul M, Bednar D, Damborsky J (2019). "Structural Biology and Protein Engineering of Thrombolytics". Computational and Structural Biotechnology Journal. 17: 917–938. doi:10.1016/j.csbj.2019.06.023. PMC 6637190. PMID 31360331.
- ^ a b c d World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 291–2. hdl:10665/44053. ISBN 9789241547659.
- ^ a b "Streptokinase 1,500,000 iu - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. 1 July 2015. Archived from the original on 20 December 2016. Retrieved 14 December 2016.
- ^ "Streptokinase Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 14 December 2016.
- ^ Sikri N, Bardia A (2007). "A history of streptokinase use in acute myocardial infarction". Texas Heart Institute Journal. 34 (3): 318–327. PMC 1995058. PMID 17948083.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "streptokinase (Intravenous route, Intracoronary route)". Truven Health Analytics. Archived from the original on 8 December 2015. Retrieved 28 November 2015.