| Streptomyces verticillus | |
|---|---|
Scientific classification 
| |
| Domain: | Bacteria |
| Phylum: | Actinomycetota |
| Class: | Actinomycetia |
| Order: | Streptomycetales |
| Family: | Streptomycetaceae |
| Genus: | Streptomyces |
| Species: | S. verticillus
|
| Binomial name | |
| Streptomyces verticillus | |
Streptomyces verticillus is a species of Gram-positive bacteria in the genus Streptomyces. Whilst screening fermentation broths of this species for bioactivity in the early 1960s, Hamao Umezawa and colleagues at the Institute of Microbial Chemistry in Tokyo identified a family of glycopeptide antitumor antibiotics called the bleomycins.[1] Examples of the bleomycins in clinical use include bleomycin A2 (also known as bleomycin) and bleomycin A5 (also known as pingyangmycin). Both are used to treat lymphomas (e.g. Hodgkin's lymphoma), head and neck cancer, and testicular cancer.[2][3]
- ^ Umezawa H, Ishizaka M, Kimura K, Iwanaga J, Takeuchi T (1968). "Biological studies on individual bleomycins". J Antibiot (Tokyo). 21 (10): 592–602. doi:10.7164/antibiotics.21.592. PMID 5752103.
- ^ "Bleomycin". US National Library of Medicine. Retrieved 5 March 2015.
- ^ Aouida M, Ramotar D (2010). "A new twist in cellular resistance to the anticancer drug bleomycin-A5". Curr Drug Metab. 11 (7): 595–602. doi:10.2174/138920010792927307. PMID 20812903.