Streptozotocin

Streptozotocin

Clinical data
Trade names	Zanosar
MedlinePlus	a684053
Routes of administration	Intravenous
ATC code	L01AD04 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	17–25% (100% if IV)
Metabolism	Liver, kidney
Elimination half-life	35–40 minutes
Identifiers
IUPAC name 2-Deoxy-2-({[methyl(nitroso)amino]carbonyl}amino)-β-D-glucopyranose
CAS Number	18883-66-4 Y
PubChem CID	29327
DrugBank	DB00428 Y
ChemSpider	27273 Y
UNII	5W494URQ81
KEGG	C07313 N
ChEBI	CHEBI:9288 Y
ChEMBL	ChEMBL450214 N
CompTox Dashboard (EPA)	DTXSID2021282
Chemical and physical data
Formula	C8H15N3O7
Molar mass	265.222 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O
InChI InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1 Y Key:ZSJLQEPLLKMAKR-GKHCUFPYSA-N Y
NY (what is this?)  (verify)

Streptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring alkylating antineoplastic agent that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. It is used in medicine for treating certain cancers of the islets of Langerhans and used in medical research to produce an animal model for hyperglycemia and Alzheimer's in a large dose, as well as type 2 diabetes or type 1 diabetes with multiple low doses.