Stress-induced-phosphoprotein 1

STIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ELR, 1ELW, 2LNI, 3ESK, 3FWV
Identifiers
Aliases	STIP1, HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L, stress induced phosphoprotein 1
External IDs	OMIM: 605063; MGI: 109130; HomoloGene: 4965; GeneCards: STIP1; OMA:STIP1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,185,272 bp[1] End 64,204,543 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 6,998,070 bp[2] End 7,017,335 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis ganglionic eminence ventricular zone right testis islet of Langerhans right adrenal gland left adrenal gland right adrenal cortex left adrenal cortex stromal cell of endometrium Top expressed in morula morula tail of embryo yolk sac epiblast blastocyst ventricular zone embryo genital tubercle neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Hsp70 protein binding protein C-terminus binding chaperone binding protein binding RNA binding Hsp90 protein binding Cellular component cytoplasm myelin sheath Golgi apparatus nucleus cytosol protein-containing complex chaperone complex Biological process response to stress cellular response to interleukin-7 Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10963 20867 Ensembl ENSG00000168439 ENSMUSG00000024966 UniProt P31948 Q60864 RefSeq (mRNA) NM_006819 NM_001282652 NM_001282653 NM_016737 RefSeq (protein) NP_001269581 NP_001269582 NP_006810 NP_058017 Location (UCSC) Chr 11: 64.19 – 64.2 Mb Chr 19: 7 – 7.02 Mb PubMed search [3] [4]
Wikidata
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Stress-induced-phosphoprotein 1 also Hsp70-Hsp90 organising protein (Hop) is encoded in the human by the STIP1 gene. It functions as a co-chaperone which reversibly links together the protein chaperones Hsp70 and Hsp90.^[5]

STI1 belongs to the large group of co-chaperones, which regulate and assist the major chaperones (mainly heat shock proteins). It is one of the best studied co-chaperones of the Hsp70-Hsp90 complex. It was first discovered in yeast and homologues were identified in humans, mice, rats, insects, plants, parasites, and viruses. The family of these proteins is referred to as STI1 (stress inducible protein) and can be divided into yeast, plant, and animal STI1 (Hop).