The Studiolo is a small painting-encrusted barrel-vaulted room in the Palazzo Vecchio, Florence, Italy. It was commissioned by Francesco I de' Medici, Grand Duke of Tuscany. It was completed for the duke from 1570 to 1572, by teams of artists under the supervision of Giorgio Vasari and the scholars Giovanni Batista Adriani and Vincenzo Borghini.
This small room was part-office, part-laboratory, part-hiding place, and part-cabinet of curiosities. Here the prince tinkered with alchemy and kept his collection of small, precious, unusual or rare objects. The walls and ceiling were decorated with paintings showing a similar variety of subjects, some showing exotic forms of industry and others mythology. The inset paintings are now all that remains in the room of the original contents. They are rather larger than what is normally meant by the term cabinet painting.
The late-Mannerist decorative program of paintings and sculpture was based on items encompassed by the collection. The object collection itself was stored in ~ 20 cabinets. In the center is a fresco of Prometheus receiving jewels from nature, commenting on the interplay of divine, nature, and humanity, that is the goal of both artistic and scientific interests.