Sugammadex

Sugammadex
Clinical data
Pronunciationsoo GAM ma dex
Trade namesBridion
Other namesORG-25969
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: B2
Routes of
administration		Intravenous
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.121.931 Edit this at Wikidata
Chemical and physical data
FormulaC72H112O48S8
Molar mass2002.12 g·mol−1
3D model (JSmol)
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  • InChI=1S/C72H112O48S8/c73-33(74)1-9-121-17-25-57-41(89)49(97)65(105-25)114-58-26(18-122-10-2-34(75)76)107-67(51(99)43(58)91)116-60-28(20-124-12-4-36(79)80)109-69(53(101)45(60)93)118-62-30(22-126-14-6-38(83)84)111-71(55(103)47(62)95)120-64-32(24-128-16-8-40(87)88)112-72(56(104)48(64)96)119-63-31(23-127-15-7-39(85)86)110-70(54(102)46(63)94)117-61-29(21-125-13-5-37(81)82)108-68(52(100)44(61)92)115-59-27(19-123-11-3-35(77)78)106-66(113-57)50(98)42(59)90/h25-32,41-72,89-104H,1-24H2,(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,83,84)(H,85,86)(H,87,88)/t25-,26-,27-,28-,29-,30-,31-,32-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-/m1/s1 ☒N
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Sugammadex, sold under the brand name Bridion, is a medication for the reversal of neuromuscular blockade induced by rocuronium and vecuronium[5] in general anaesthesia. It is the first selective relaxant binding agent (SRBA). It is marketed by Merck.[8]

The most common side effects include cough, airway problems due to the anaesthesia wearing off, reduced blood pressure and other complications such as changes in heart rate.[6]

Sugammadex is available as a generic medication.[9]

  1. ^ SUGAMMADEX ACCORD (Accord Healthcare Pty Ltd) Archived 2022-10-12 at the Wayback Machine Department of Health and Aged Care. Retrieved 30 March 2023
  2. ^ SUGAMMADEX SANDOZ (Sandoz Pty Ltd) Archived 2022-10-12 at the Wayback Machine Department of Health and Aged Care. Retrieved 30 March 2023
  3. ^ "Health Canada New Drug Authorizations: 2016 Highlights". Health Canada. 14 March 2017. Retrieved 7 April 2024.
  4. ^ "Bridion 100 mg/ml solution for injection - Summary of Product Characteristics (SmPC)". (emc). 18 March 2021. Archived from the original on 27 June 2021. Retrieved 27 June 2021.
  5. ^ a b Cite error: The named reference Bridion FDA label was invoked but never defined (see the help page).
  6. ^ a b "Bridion EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 10 June 2020. Retrieved 10 June 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  7. ^ "Sugammadex Adroiq". Union Register of medicinal products. 30 May 2023. Retrieved 6 June 2023.
  8. ^ "Dosing for Bridion (sugammadex)". www.merckconnect.com. Archived from the original on 2019-01-12. Retrieved 2019-01-11.
  9. ^ "Sugammadex Adroiq". European Medicines Agency. 16 June 2023. Retrieved 19 June 2023.