Sulfadimethoxine

Sulfadimethoxine
Clinical data
Trade namesAlbon, Di-Methox
AHFS/Drugs.comFDA Professional Drug Information
Routes of
administration		By mouth; can be IV in cattle[1]
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only (by veterinarian)
Pharmacokinetic data
Bioavailability55–60%[2]
Elimination half-life13.1 hours in dogs[2]
Identifiers
  • 4-Amino-N-(2,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.004.113 Edit this at Wikidata
Chemical and physical data
FormulaC12H14N4O4S
Molar mass310.33 g·mol−1
3D model (JSmol)
  • COc1cc(nc(n1)OC)NS(=O)(=O)c2ccc(cc2)N
  • InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16) checkY
  • Key:ZZORFUFYDOWNEF-UHFFFAOYSA-N checkY
  (verify)

Sulfadimethoxine (or sulphadimethoxine, trade names Di-Methox or Albon) is a long-lasting sulfonamide antimicrobial medication used in veterinary medicine. It is used to treat many infections, including respiratory, urinary tract, enteric, and soft tissue infections[3] and can be given as a standalone or combined with ormetoprim to broaden the target range.[2] Like all sulfamides, sulfadimethoxine inhibits bacterial synthesis of folic acid by acting as a competitive inhibitor against PABA. It is the most common drug prescribed to dogs who have coccidiosis.[4]

  1. ^ "SulfaMed (sulfadimethoxine) Injection 40% for Animal Use". Drugs.com. Retrieved 2017-06-18.
  2. ^ a b c Riviere JE, Papich MG (2013-05-13). Veterinary Pharmacology and Therapeutics. John Wiley & Sons. pp. 836, 845, 857, 1169. ISBN 9781118685907.
  3. ^ "ALBON – sulfadimethoxine suspension". DailyMed. US National Library of Medicine. 2014-05-21. Retrieved 2017-06-17.
  4. ^ Ward E (2008-12-08). "Coccidiosis in Dogs". Know Your Pet. VCA Hospitals. Retrieved 2017-06-18.