Sulfotep

Sulfotep
Ball-and-stick model of the sulfotep molecule
Names
Preferred IUPAC name
O1,O1,O3,O3-Tetraethyl 1,3-dithiodiphosphate
Other names
Sulfotep, Dithiophos, Dithion, Bladafum, Dithiofos, Dithione, Dithiotep, Pirofos, TEDP[1][2]
Identifiers
3D model (JSmol)
ECHA InfoCard 100.020.905 Edit this at Wikidata
EC Number
  • 222-995-2
RTECS number
  • XN4375000
UNII
UN number 1704
  • CCOP(=S)(OCC)OP(=S)(OCC)OCC
Properties
C8H20O5P2S2
Molar mass 322.31 g·mol−1
Appearance Pale yellow liquid[3]
Odor Garlic-like[3]
Density 1.196 g/cm3
Boiling point 136 to 139 °C (277 to 282 °F; 409 to 412 K) at 2 mm Hg
30 mg/L
Vapor pressure 0.0002 mmHg (20°C)[3]
Hazards[6][7]
Occupational safety and health (OHS/OSH):
Main hazards
 Poison[4]
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 4: Very short exposure could cause death or major residual injury. E.g. VX gasFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
4
1
0
Flash point −18 °C (0 °F; 255 K)
Lethal dose or concentration (LD, LC):
22 mg/kg (mouse, oral)
25 mg/kg (rabbit, oral)
5 mg/kg (dog, oral)
5 mg/kg (rat, oral)[5]
38 mg/m3 (rat, 4 hr)
40 mg/m3 (mouse, 4 hr)[5]
NIOSH (US health exposure limits):
PEL (Permissible)
 TWA 0.2 mg/m3 [skin][3]
IDLH (Immediate danger)
 10 mg/m3[3]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Sulfotep (also known as tetraethyldithiopyrophosphate and TEDP[8]) is a pesticide commonly used in greenhouses as a fumigant. The substance is also known as Dithione, Dithiophos, and many other names. Sulfotep has the molecular formula C8H20O5P2S2 and belongs to the organophosphate class of chemicals. It has a cholinergic effect, involving depression of the cholinesterase activity of the peripheral and central nervous system of insects.[7] The transduction of signals is disturbed at the synapses that make use of acetylcholine. Sulfotep is a mobile oil that is pale yellow-colored and smells like garlic.[8][9] It is primarily used as an insecticide.

  1. ^ Eula Bingham, Barbara Cohrssen, and Charles H. Powell. Patty's toxicology. Vol. 7 (5th ed.). John Wiley and Sons.{{cite book}}: CS1 maint: multiple names: authors list (link)
  2. ^ CID 19395 from PubChem
  3. ^ a b c d e NIOSH Pocket Guide to Chemical Hazards. "#0586". National Institute for Occupational Safety and Health (NIOSH).
  4. ^ Sulfotep toxicity
  5. ^ a b "TEDP". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
  6. ^ Product detail chemkoo.com [dead link]
  7. ^ a b Georg Kimmerle and Otto R. Klimmer, ‘’Acute and Subchronic Toxicity of Sulfotep’’, Arch. Toxicol. 33, 1-16 (1974)
  8. ^ a b Tetraethyl dithiopyrophosphate, retrieved July 30, 2013
  9. ^ TETRAETHYL DITHIOPYROPHOSPHATE, retrieved July 29, 2013