Sulindac

Sulindac
Clinical data
Trade namesClinoril
AHFS/Drugs.comMonograph
MedlinePlusa681037
Pregnancy
category
  • AU: C
Routes of
administration
By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
BioavailabilityApproximately 90% (Oral)
Metabolism?
Elimination half-life7.8 hours, metabolites up to 16.4 hours
ExcretionRenal (50%) and fecal (25%)
Identifiers
  • {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-indene-3-yl}acetic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.048.909 Edit this at Wikidata
Chemical and physical data
FormulaC20H17FO3S
Molar mass356.41 g·mol−1
3D model (JSmol)
Melting point182 to 185 °C (360 to 365 °F) (decomp.)
  • O=S(c1ccc(cc1)\C=C3/c2ccc(F)cc2\C(=C3C)CC(=O)O)C
  • InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9- checkY
  • Key:MLKXDPUZXIRXEP-MFOYZWKCSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed as Clinoril. Imbaral (not to be confused with mebaral) is another name for this drug. Its name is derived from sul(finyl)+ ind(ene)+ ac(etic acid) It was patented in 1969 and approved for medical use in 1976.[1]

  1. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 517. ISBN 9783527607495.