Super Conserved Receptor Expressed in Brain

For the American educational organization, see Southern Regional Education Board.
G protein-coupled receptor 27
Identifiers
SymbolGPR27
Alt. symbolsSREB1
NCBI gene2850
HGNC4482
OMIM605187
RefSeqNM_018971
UniProtQ9NS67
Other data
LocusChr. 3 p21-p14
Search for
StructuresSwiss-model
DomainsInterPro
G protein-coupled receptor 85
Identifiers
SymbolGPR85
Alt. symbolsSREB2
NCBI gene54329
HGNC4536
OMIM605188
RefSeqNM_018970
UniProtP60893
Other data
LocusChr. 7 q31
Search for
StructuresSwiss-model
DomainsInterPro
G protein-coupled receptor 173
Identifiers
SymbolGPR173
Alt. symbolsSREB3
NCBI gene54328
HGNC18186
OMIM300253
RefSeqNM_018969
UniProtQ9NS66
Other data
LocusChr. X p11
Search for
StructuresSwiss-model
DomainsInterPro

The Super Conserved Receptor Expressed in Brain (SREB) family are a group of related G-protein coupled receptors.[1] Since no endogenous ligands have yet been identified for these receptors, they are classified as orphan receptors. Receptors within the group include SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173).[2]

  1. ^ Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, Tadokoro M, Matsumoto S, Ohishi T, Furuichi K (2000). "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system". Biochem. Biophys. Res. Commun. 272 (2): 576–82. doi:10.1006/bbrc.2000.2829. PMID 10833454.
  2. ^ National Center for Biotechnology Information, [https://www.ncbi.nlm.nih.gov/Structure/cdd/cd15216 Conserved Protein Domain Family 7tmA_SREB1_GPR27], accessed 5 February 2022