Surfactant protein A1

SFTPA1
Identifiers
Aliases	SFTPA1, COLEC4, PSAP, PSP-A, PSPA, SFTP1, SFTPA1B, SP-A, SP-A1, SPA, SPA1, surfactant protein A1, SP-A1 beta, SP-A1 delta, SP-A1 gamma, SP-A1 epsilon, ILD1
External IDs	OMIM: 178630; MGI: 109518; HomoloGene: 3946; GeneCards: SFTPA1; OMA:SFTPA1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	79,615,455 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	40,858,409 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; apex of heart; ; gonad; ; islet of Langerhans; ; gastrocnemius muscle; ; left ventricle; ; right lobe of thyroid gland; ; appendix; ; sural nerve;
	Top expressed in
	right lung lobe; ; left lung; ; left lung lobe; ; trachea; ; alveolar duct; ; sexually immature organism; ; pulmonary alveolus; ; carotid body; ; aorta; ; liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; carbohydrate binding; lipid transporter activity; lipopolysaccharide binding; monosaccharide binding;
Cellular component	extracellular region; clathrin-coated endocytic vesicle; collagen; lamellar granule; endoplasmic reticulum membrane; extracellular space; multivesicular body; rough endoplasmic reticulum;
Biological process	respiratory gaseous exchange by respiratory system; lipid transport; toll-like receptor signaling pathway; opsonization; surfactant homeostasis; positive regulation of phagocytosis; developmental process;
	Sources:Amigo / QuickGO
Orthologs
	653509
	20387
	ENSG00000122852
	ENSMUSG00000021789
	Q8IWL2
	P35242; Q9CQI1
NM_001093770; NM_001164644; NM_001164645; NM_001164646; NM_001164647;
	NM_005411
	NM_023134
NP_001087239; NP_001158116; NP_001158117; NP_001158118; NP_001158119;
	NP_005402
	NP_075623
	Wikidata
View/Edit Human	View/Edit Mouse

Surfactant protein A1 (SP-A1), also known as Pulmonary surfactant-associated protein A1 (PSP-A) is a protein that in humans is encoded by the SFTPA1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122852 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021789 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Surfactant protein A1".
^ Silveyra P, Floros J (Dec 2013). "Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2". Gene. 531 (2): 126–32. doi:10.1016/j.gene.2012.09.111. PMC 3570704. PMID 23069847.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122852 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021789 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Surfactant protein A1".

[pmid23069847-6] Silveyra P, Floros J (Dec 2013). "Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2". Gene. 531 (2): 126–32. doi:10.1016/j.gene.2012.09.111. PMC 3570704. PMID 23069847.

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