Susan M. Berget is a biochemist and professor emerita at the Baylor College of Medicine. Originally involved in the MIT lab of Phillip Sharp for her postdoctoral fellowship, she was instrumental in the research that led to the discovery of RNA splicing and split genes, which awarded Sharp the 1993 Nobel Prize in Physiology or Medicine. Berget was excluded, however, from receiving credit, which inhibited her attempts to apply for a professorship afterwards, particularly due to Sharp's letter of recommendation also not giving her credit for the research in his lab. Eventually, Nancy Hopkins and David Botstein convinced Sharp to rewrite his letter, allowing Berget to receive a professor invitation from Rice University.
She went on to become a professor at the Baylor College of Medicine, where her research focused on further understanding exons, introns, and the overall mechanisms of RNA splicing. Her research has been highly influential in figuring out the exon definition and recognition system of cells, along with the biochemical factors that help determine how splice sites are determined.