Susan Gottesman

Susan Gottesman
NIH photo of Susan Gottesman
Born (1945-05-19) May 19, 1945 (age 79)
New York, New York
Alma mater
Known for
Scientific career
Fields
  • Genetics
  • Microbial biology
Institutions
Thesis (1972)

Susan Gottesman is a microbiologist at the National Cancer Institute (NCI), which is part of the National Institutes of Health.[1] Gottesman has been the editor of the Annual Review of Microbiology since 2008.[2]

She is a pioneer in the area of biological regulation in which enzymes that destroy specific other proteins, called proteases, play a central role inside the cell. She discovered and elucidated the central features of a new family of proteases that require energy for their function in the form of ATP-hydrolysis.[3][4] She has also played a major role in the discovery and characterization of bacterial small RNAs.[5]

  1. ^ "Susan Gottesman, Ph.D." Center for Cancer Research. August 12, 2014. Retrieved December 6, 2019.
  2. ^ Ornston, Nick (2007). "Preface by Nick Ornston". Annual Review of Microbiology. 61. doi:10.1146/annurev.mi.61.092607.100001.
  3. ^ Koodathingal, Prakash; Jaffe, Neil E.; Kraut, Daniel A.; Prakash, Sumit; Fishbain, Susan; Herman, Christophe; Matouschek, Andreas (July 10, 2009). "ATP-dependent proteases differ substantially in their ability to unfold globular proteins". The Journal of Biological Chemistry. 284 (28): 18674–18684. doi:10.1074/jbc.M900783200. ISSN 0021-9258. PMC 2707231. PMID 19383601.
  4. ^ Gottesman, Susan; Gant, Jason (October 1, 2008). "NCI Laboratory of Molecular Biology Oral History Project" (PDF).
  5. ^ "Prokaryotic Pioneer". The Scientist Magazine®. Retrieved December 6, 2019.