Susan J. Clark

Professor
Susan J. Clark
FAA FAHMS
EducationHonours: Australian National University, 1978 PhD: University of Adelaide, 1982
OccupationScientist
TitleProfessor
Websitehttps://www.garvan.org.au/people/researchers/susan-clark

Susan J. Clark is an Australian biomedical researcher in epigenetics of development and cancer. She was elected a Fellow of the Australian Academy of Science in 2015,[1] and is a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellow and Research Director and Head of Genomics and Epigenetics Division at the Garvan Institute of Medical Research.[2] Clark developed the first method for bisulphite sequencing[3] for DNA methylation analysis and used it to establish that the methylation machinery of mammalian cells is capable of both maintenance and de novo methylation at CpNpG sites and showed is inheritable.[4] Clark's research has advanced understanding of the role of DNA methylation, non-coding RNA and microRNA in embryogenesis, reprogramming, stem cell development and cancer, and has led to the identification of epigenomic biomarkers in cancer.[5][6] Clark is a founding member of the International Human Epigenome Consortium (IHEC) and President of the Australian Epigenetics Alliance (AEpiA).[7]

  1. ^ Australian Academy of Science (2024). "Australian Academy of Science: Susan Clark".
  2. ^ "Prof Susan Clark". Garvan Institute of Medical Research.
  3. ^ Susan, J.CIark; Harrison, Janet; Paul, Cheryl L.; Frommer, Marianne (1994). "High sensitivity mapping of methylated cytosines". Nucleic Acids Research. 22 (15): 2990–2997. doi:10.1093/nar/22.15.2990. ISSN 0305-1048. PMC 310266. PMID 8065911.
  4. ^ Clark, Susan J.; Harrison, Janet; Frommer, Marianne (May 1995). "CpNpG methylation in mammalian cells". Nature Genetics. 10 (1): 20–27. doi:10.1038/ng0595-20. ISSN 1061-4036. PMID 7647784. S2CID 8857760.
  5. ^ "Hormone resistance in breast cancer linked to DNA 'rewiring'". ScienceDaily. Retrieved 22 February 2021.
  6. ^ "CNIO team develop a technology to improve effectiveness of stem cells in regenerative medicine". EurekAlert!. Retrieved 22 February 2021.
  7. ^ "AEpiA Committee | Australian Epigenetics Alliance".