Sydney Brenner

Sydney Brenner
CH FRS FMedSci MAE
Brenner in 2008
Born(1927-01-13)13 January 1927
Germiston, Transvaal, South Africa
Died5 April 2019(2019-04-05) (aged 92)
Singapore
Other namesUncle Syd[10]
Alma mater
Known forGenetics of Caenorhabditis elegans[11][12]
Spouse
May Covitz
​
​
(m. 1952; died 2010)​
[2]
Children3
Awards
Scientific career
FieldsBiology
Institutions
ThesisThe physical chemistry of cell processes: a study of bacteriophage resistance in Escherichia coli, strain B (1954)
Doctoral advisorCyril Hinshelwood[6][7]
Doctoral students

Sydney Brenner CH FRS FMedSci MAE (13 January 1927 – 5 April 2019)[13][14] was a South African biologist. In 2002, he shared the Nobel Prize in Physiology or Medicine with H. Robert Horvitz and Sir John E. Sulston.[10] Brenner made significant contributions to work on the genetic code, and other areas of molecular biology while working in the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge, England. He established the roundworm Caenorhabditis elegans as a model organism for the investigation of developmental biology,[11][15] and founded the Molecular Sciences Institute in Berkeley, California, United States.[16][17][18][19][20][21][22][23]

  1. ^ "Louis-Jeantet Prize". Archived from the original on 4 September 2018. Retrieved 4 September 2018.
  2. ^ a b Cite error: The named reference whoswho was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference scripps was invoked but never defined (see the help page).
  4. ^ "Janelia Farm: Sydney Brenner". hhmi.org. Archived from the original on 27 December 2007.
  5. ^ "Research Units | Okinawa Institute of Science and Technology Graduate University OIST". Oist.jp. 1 February 2016. Archived from the original on 17 May 2020. Retrieved 1 December 2016.
  6. ^ Thompson, H. (1973). "Cyril Norman Hinshelwood 1897-1967". Biographical Memoirs of Fellows of the Royal Society. 19: 374–431. doi:10.1098/rsbm.1973.0015. PMID 11615727. S2CID 12385145.
  7. ^ Cite error: The named reference phd was invoked but never defined (see the help page).
  8. ^ Rubin, Gerald Mayer (1974). Studies on 5.8 S Ribosomal RNA (PhD thesis). University of Cambridge. OCLC 500553465. EThOS uk.bl.ethos.471132. Archived from the original on 6 April 2019. Retrieved 13 November 2017.
  9. ^ White, John Graham (1974). Computer Aided Reconstruction of the Nervous System of Caenorhabditis Elegans (PhD thesis). University of Cambridge. OCLC 180702071. EThOS uk.bl.ethos.477040. Archived from the original on 6 April 2019. Retrieved 13 November 2017.
  10. ^ a b Friedberg, Errol (2019). "Sydney Brenner (1927–2019) Mischievous steward of molecular biology's golden age". Nature. 568 (7753): 459. doi:10.1038/d41586-019-01192-9. ISSN 0028-0836. PMID 30988427.
  11. ^ a b Brenner, Sydney (1974). "The genetics of Caenorhabditis elegans". Genetics. 77 (1): 71–94. doi:10.1093/genetics/77.1.71. PMC 1213120. PMID 4366476.
  12. ^ Sulston, J.; Brenner, S. (1974). "The DNA of Caenorhabditis elegans". Genetics. 77 (1): 95–104. doi:10.1093/genetics/77.1.95. PMC 1213121. PMID 4858229.
  13. ^ Wade, Nicholas (5 April 2019). "Sydney Brenner, a Decipherer of the Genetic Code, Is Dead at 92". The New York Times. Archived from the original on 5 April 2019. Retrieved 8 April 2019.
  14. ^ White, John; Bretscher, Mark S. (2020). "Sydney Brenner. 13 January 1927—5 April 2019". Biographical Memoirs of Fellows of the Royal Society. 69: 78–108. doi:10.1098/rsbm.2020.0022. S2CID 221399685.
  15. ^ Hodgkin, JA; Brenner, S (1977). "Mutations causing transformation of sexual phenotype in the nematode Caenorhabditis elegans". Genetics. 86 (2 Pt. 1): 275–87. doi:10.1093/genetics/86.2.275. ISSN 0016-6731. PMC 1213677. PMID 560330.
  16. ^ The Science Times Book of the Brain 1998. Edited by Nicholas Wade. The Lyons Press
  17. ^ Horace Freeland Judson The Eighth Day of Creation (1979), pp. 10–11 Makers of the Revolution in Biology; Penguin Books 1995, first published by Jonathan Cape, 1977; ISBN 0-14-017800-7.
  18. ^ Brenner, S.; Elgar, G.; Sanford, R.; Macrae, A.; Venkatesh, B.; Aparicio, S. (1993). "Characterization of the pufferfish (Fugu) genome as a compact model vertebrate genome". Nature. 366 (6452): 265–68. Bibcode:1993Natur.366..265B. doi:10.1038/366265a0. ISSN 0028-0836. PMID 8232585. S2CID 2715056.
  19. ^ "Sydney Brenner: A Biography" by Errol Friedberg, pub. CSHL Press October 2010, ISBN 0-87969-947-7.
  20. ^ de Chadarevian, Soraya (2009). "Interview with Sydney Brenner". Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences. 40 (1): 65–71. doi:10.1016/j.shpsc.2008.12.008. ISSN 1369-8486. PMID 19268875.
  21. ^ Friedberg, Errol C. (2008). "Sydney Brenner". Nature Reviews Molecular Cell Biology. 9 (1): 8–9. doi:10.1038/nrm2320. ISSN 1471-0072. PMID 18159633. S2CID 1037231.
  22. ^ Sydney Brenner's publications indexed by the Scopus bibliographic database. (subscription required)
  23. ^ "Sydney Brenner publications". Google Scholar. Archived from the original on 18 September 2019. Retrieved 28 September 2008.