| Synaptotagmin | |
|---|---|
 Molecular machinery driving exocytosis in neurotransmitter release: the core SNARE complex (formed by four α-helices contributed by synaptobrevin, syntaxin and SNAP-25) and the Ca2+ sensor synaptotagmin.[1] | |
| Identifiers | |
| Symbol | SYT |
| OPM superfamily | 45 |
| OPM protein | 3hn8 |
| Membranome | 199 |
Synaptotagmins (SYTs) constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 17 isoforms in the mammalian synaptotagmin family.[2] There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, Extended-Synaptotagmin (E-Syt) membrane proteins, and MCTPs) and soluble (RIMS1 and RIMS2, UNC13D, synaptotagmin-related proteins and B/K) proteins. The family includes synaptotagmin 1, a Ca2+ sensor in the membrane of the pre-synaptic axon terminal, coded by gene SYT1.[3]
- ^ Georgiev DD, Glazebrook JF (2007). "Subneuronal processing of information by solitary waves and stochastic processes". In Lyshevski SE (ed.). Nano and Molecular Electronics Handbook. Nano and Microengineering Series. CRC Press. pp. 17–1–17-41. doi:10.1201/9781315221670-17. ISBN 978-0-8493-8528-5.
- ^ Dean C, Dunning FM, Liu H, Bomba-Warczak E, Martens H, Bharat V, et al. (May 2012). "Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen". Molecular Biology of the Cell. 23 (9): 1715–27. doi:10.1091/mbc.E11-08-0707. PMC 3338438. PMID 22398727.
- ^ "NIH VideoCast - Ca2+ Sensors for Exocytosis". videocast.nih.gov. Retrieved 16 April 2018.