Synovitis

For the condition of inflammation of the nasal sinuses, see Sinusitis.
Synovitis
Chronic synovitis
SpecialtyRheumatology

Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints that possess cavities, known as synovial joints. The condition is usually painful, particularly when the joint is moved. The joint usually swells due to synovial fluid collection.

Watercolour drawing of acute synovitis of the knee joint, showing the beginnings of the disintegration of the cartilage of the internal condyle. Painted by Thomas Godart.
Medical Photographic Library

Synovitis may occur in association with arthritis as well as lupus, gout, and other conditions. Synovitis is more commonly found in rheumatoid arthritis than in other forms of arthritis, and can thus serve as a distinguishing factor, although it is also present in many joints affected with osteoarthritis.[1][2] In rheumatoid arthritis, the fibroblast-like synoviocytes, highly specialized mesenchymal cells found in the synovial membrane, play an active and prominent role in the synovitis.[3] Long term occurrence of synovitis can result in degeneration of the joint.

  1. ^ Sutton S, Clutterbuck A, Harris P, Gent T, Freeman S, Foster N, Barrett-Jolley R, Mobasheri A (2009). "The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis". The Veterinary Journal. 179 (1): 10–24. doi:10.1016/j.tvjl.2007.08.013. PMID 17911037.
  2. ^ Scanzello, C. R.; Goldring, S. R. (2012). "The role of synovitis in osteoarthritis pathogenesis". Bone. 51 (2): 249–57. doi:10.1016/j.bone.2012.02.012. PMC 3372675. PMID 22387238.
  3. ^ Nygaard, Gyrid; Firestein, Gary S. (2020). "Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes". Nature Reviews Rheumatology. 16 (6): 316–333. doi:10.1038/s41584-020-0413-5. PMC 7987137. PMID 32393826. S2CID 218573182.