TAC1

TAC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KS9, 2KSA, 2KSB, 4HOM,%%s2B19,%%s2B19
Identifiers
Aliases	TAC1, Hs.2563, NK2, TAC2, tachykinin precursor 1, NKNA, NPK
External IDs	OMIM: 162320; MGI: 98474; HomoloGene: 2394; GeneCards: TAC1; OMA:TAC1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	97,740,472 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	7,565,834 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; external globus pallidus; ; endothelial cell; ; putamen; ; dorsal motor nucleus of vagus nerve; ; caudate nucleus; ; nucleus accumbens; ; middle frontal gyrus; ; trigeminal ganglion; ; superior vestibular nucleus;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; ventromedial nucleus; ; ventral tegmental area; ; dorsomedial hypothalamic nucleus; ; mammillary body; ; anterior amygdaloid area; ; globus pallidus; ; habenula; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signaling receptor binding; substance P receptor binding;
Cellular component	plasma membrane; extracellular region; axon; soma; extracellular space;
Biological process	cellular response to nerve growth factor stimulus; response to yeast; associative learning; positive regulation of renal sodium excretion; positive regulation of cytosolic calcium ion concentration; cell-cell signaling; antibacterial humoral response; positive regulation of synaptic transmission, cholinergic; positive regulation of epithelial cell migration; positive regulation of ossification; positive regulation of synaptic transmission, GABAergic; negative regulation of heart rate; positive regulation of corticosterone secretion; regulation of blood pressure; positive regulation of action potential; response to morphine; response to lipopolysaccharide; long-term memory; response to pain; defense response to Gram-negative bacterium; positive regulation of saliva secretion; positive regulation of acute inflammatory response; insemination; response to hormone; sensory perception of pain; detection of abiotic stimulus; innate immune response; neuropeptide signaling pathway; positive regulation of lymphocyte proliferation; positive regulation of stress fiber assembly; antifungal humoral response; defense response to Gram-positive bacterium; chemical synaptic transmission; inflammatory response; tachykinin receptor signaling pathway; antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6863
	21333
	ENSG00000006128
	ENSMUSG00000061762
	P20366
	P41539
	NM_013998; NM_003182; NM_013996; NM_013997
	NM_009311; NM_001311060
	NP_003173; NP_054702; NP_054703; NP_054704
	NP_001297989; NP_033337
	Wikidata
View/Edit Human	View/Edit Mouse

Preprotachykinin-1, (abbreviated PPT-1, PPT-I, or PPT-A), is a precursor protein that in humans is encoded by the TAC1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006128 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061762 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chiwakata C, Brackmann B, Hunt N, Davidoff M, Schulze W, Ivell R (May 1991). "Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis". Endocrinology. 128 (5): 2441–8. doi:10.1210/endo-128-5-2441. PMID 1708336.
^ "Entrez Gene: TAC1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006128 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061762 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1708336-5] Chiwakata C, Brackmann B, Hunt N, Davidoff M, Schulze W, Ivell R (May 1991). "Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis". Endocrinology. 128 (5): 2441–8. doi:10.1210/endo-128-5-2441. PMID 1708336.

[entrez-6] "Entrez Gene: TAC1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)".

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