TAF1

TAF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EQF, 3AAD, 3UV4, 3UV5, 4RGW, 4YYM, 4YYN, 5I29, 5I1Q, 5FUR
Identifiers
Aliases	TAF1, BA2R, CCG1, CCGS, DYT3, DYT3/KAT4, N-NSCL2, OF, P250, TAF(II)250, TAF2A, TAFII-250, TAFII250, XDP, MRXS33, TATA-box binding protein associated factor 1
External IDs	OMIM: 313650; MGI: 1336878; HomoloGene: 37942; GeneCards: TAF1; OMA:TAF1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 71,366,222 bp[1] End 71,532,374 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X D|X 44.29 cM Start 100,576,340 bp[2] End 100,645,395 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon epithelium of colon urethra tonsil left ovary lactiferous duct pericardium corpus callosum body of uterus Top expressed in hand neural layer of retina dentate gyrus of hippocampal formation granule cell Gonadal ridge Rostral migratory stream ventricular zone maxillary prominence ventral tegmental area tail of embryo arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding DNA binding transcription coactivator activity p53 binding transcription factor binding protein binding lysine-acetylated histone binding TBP-class protein binding acyltransferase activity ATP binding protein serine/threonine kinase activity histone acetyltransferase activity kinase activity protein heterodimerization activity H3K27me3 modified histone binding ubiquitin conjugating enzyme activity acetyl-CoA binding sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II general transcription initiation factor activity Cellular component nucleoplasm MLL1 complex nucleus nucleolus transcription regulator complex transcription factor TFIID complex Biological process phosphorylation RNA polymerase II preinitiation complex assembly transcription by RNA polymerase II positive regulation of transcription initiation from RNA polymerase II promoter transcription, DNA-templated peptidyl-serine phosphorylation DNA-templated transcription, initiation protein autophosphorylation cell cycle transcription initiation from RNA polymerase II promoter peptidyl-threonine phosphorylation positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of transcription by RNA polymerase II regulation of signal transduction by p53 class mediator viral process histone acetylation protein polyubiquitination protein phosphorylation cellular response to DNA damage stimulus negative regulation of gene expression midbrain development positive regulation of protein binding cellular response to UV transcription factor catabolic process protein stabilization regulation of transcription initiation from RNA polymerase II promoter cellular response to ATP regulation of cell cycle G1/S phase transition negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding negative regulation of protein autoubiquitination negative regulation of ubiquitin-dependent protein catabolic process positive regulation of androgen receptor activity positive regulation of transcription by RNA polymerase I regulation of transcription, DNA-templated negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage negative regulation of DNA-binding transcription factor activity ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6872 270627 Ensembl ENSG00000147133 ENSMUSG00000031314 UniProt P21675 Q80UV9 RefSeq (mRNA) NM_001286074 NM_004606 NM_138923 NM_001081008 NM_001290729 RefSeq (protein) NP_001273003 NP_004597 NP_620278 NP_001277658 NP_001392888 NP_001392889 NP_001392890 NP_001392891 Location (UCSC) Chr X: 71.37 – 71.53 Mb Chr X: 100.58 – 100.65 Mb PubMed search [3] [4]
Wikidata
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Transcription initiation factor TFIID subunit 1, also known as transcription initiation factor TFIID 250 kDa subunit (TAFII-250) or TBP-associated factor 250 kDa (p250), is a protein that in humans is encoded by the TAF1 gene.^[5][6]