TAP1

TAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JJ7
Identifiers
Aliases	TAP1, ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), transporter 1, ATP binding cassette subfamily B member
External IDs	OMIM: 170260; MGI: 98483; HomoloGene: 495; GeneCards: TAP1; OMA:TAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,853,816 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,416,199 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; appendix; ; lymph node; ; blood; ; spleen; ; monocyte; ; duodenum; ; skin of abdomen; ; skin of leg; ; upper lobe of left lung;
	Top expressed in
	mesenteric lymph nodes; ; granulocyte; ; thymus; ; spleen; ; mucous cell of stomach; ; intestinal villus; ; jejunum; ; Ileal epithelium; ; duodenum; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	MHC protein binding; nucleotide binding; protein homodimerization activity; ABC-type peptide transporter activity; TAP2 binding; MHC class Ib protein binding; ATPase activity; protein binding; MHC class I protein binding; TAP1 binding; ATP binding; peptide antigen binding; ADP binding; ATPase-coupled transmembrane transporter activity; ABC-type peptide antigen transporter activity; peptide transmembrane transporter activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; TAP complex; integral component of endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum; microtubule organizing center; phagocytic vesicle membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; MHC class I peptide loading complex;
Biological process	defense response; adaptive immune response; immune system process; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I; protein transport; peptide transport; viral process; cytosol to endoplasmic reticulum transport; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane; transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	6890
	21354
ENSG00000226173; ENSG00000168394; ENSG00000224212; ENSG00000230705; ENSG00000206297;
	ENSG00000227816; ENSG00000224748; ENSG00000232367
	ENSMUSG00000037321
	Q03518
	P21958
	NM_001292022; NM_000593
	NM_001161730; NM_013683
	NP_000584; NP_001278951
	NP_001155202; NP_038711
	Wikidata
View/Edit Human	View/Edit Mouse

Transporter associated with antigen processing 1 (TAP1) is a protein that in humans is encoded by the TAP1 gene. A member of the ATP-binding cassette transporter family, it is also known as ABCB2.^[5]^[6]

^ ^a ^b ^c ENSG00000168394, ENSG00000224212, ENSG00000230705, ENSG00000206297, ENSG00000227816, ENSG00000224748, ENSG00000232367 GRCh38: Ensembl release 89: ENSG00000226173, ENSG00000168394, ENSG00000224212, ENSG00000230705, ENSG00000206297, ENSG00000227816, ENSG00000224748, ENSG00000232367 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037321 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–173. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427.
^ Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A. 88 (22): 10094–10098. Bibcode:1991PNAS...8810094B. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428.

[refGRCh38Ensembl-1] ENSG00000168394, ENSG00000224212, ENSG00000230705, ENSG00000206297, ENSG00000227816, ENSG00000224748, ENSG00000232367 GRCh38: Ensembl release 89: ENSG00000226173, ENSG00000168394, ENSG00000224212, ENSG00000230705, ENSG00000206297, ENSG00000227816, ENSG00000224748, ENSG00000232367 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037321 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1529427-5] Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–173. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427.

[pmid1946428-6] Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A. 88 (22): 10094–10098. Bibcode:1991PNAS...8810094B. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428.

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