TAP2

TAP2
Identifiers
Aliases	TAP2, ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), transporter 2, ATP binding cassette subfamily B member
External IDs	OMIM: 170261; MGI: 98484; HomoloGene: 37323; GeneCards: TAP2; OMA:TAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,838,739 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,435,295 bp
RNA expression pattern
	Top expressed in
	appendix; ; lymph node; ; monocyte; ; granulocyte; ; duodenum; ; apex of heart; ; spleen; ; stromal cell of endometrium; ; mucosa of transverse colon; ; blood;
	Top expressed in
	thymus; ; granulocyte; ; mesenteric lymph nodes; ; lactiferous gland; ; spleen; ; duodenum; ; subcutaneous adipose tissue; ; jejunum; ; bone marrow; ; submandibular gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	MHC protein binding; ATPase-coupled transmembrane transporter activity; nucleotide binding; ABC-type peptide transporter activity; transporter activity; tapasin binding; MHC class Ib protein binding; ABC-type peptide antigen transporter activity; ATPase activity; protein binding; TAP1 binding; ATP binding; peptide transmembrane transporter activity; MHC class I protein binding; TAP2 binding;
Cellular component	TAP complex; endoplasmic reticulum membrane; membrane; integral component of endoplasmic reticulum membrane; integral component of membrane; endoplasmic reticulum; nuclear speck; phagocytic vesicle membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; MHC class I peptide loading complex;
Biological process	adaptive immune response; immune system process; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; transmembrane transport; protein transport; peptide transport; viral process; cytosol to endoplasmic reticulum transport; antigen processing and presentation of endogenous peptide antigen via MHC class I; peptide antigen transport; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane; transport;
	Sources:Amigo / QuickGO
Orthologs
	6891
	21355
ENSG00000204267; ENSG00000206299; ENSG00000228582; ENSG00000206235; ENSG00000225967;
	ENSG00000237599; ENSG00000223481; ENSG00000232326
	ENSMUSG00000024339
	Q03519
	P36371
	NM_018833; NM_000544; NM_001290043
	NM_011530
	NP_000535; NP_001276972; NP_061313
	NP_035660
	Wikidata
View/Edit Human	View/Edit Mouse

TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2.^[5]^[6]^[7]

^ ^a ^b ^c ENSG00000206299, ENSG00000228582, ENSG00000206235, ENSG00000225967, ENSG00000237599, ENSG00000223481, ENSG00000232326 GRCh38: Ensembl release 89: ENSG00000204267, ENSG00000206299, ENSG00000228582, ENSG00000206235, ENSG00000225967, ENSG00000237599, ENSG00000223481, ENSG00000232326 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024339 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–73. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427.
^ Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A. 88 (22): 10094–8. Bibcode:1991PNAS...8810094B. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428.
^ Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet. 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595. S2CID 21059468.

[refGRCh38Ensembl-1] ENSG00000206299, ENSG00000228582, ENSG00000206235, ENSG00000225967, ENSG00000237599, ENSG00000223481, ENSG00000232326 GRCh38: Ensembl release 89: ENSG00000204267, ENSG00000206299, ENSG00000228582, ENSG00000206235, ENSG00000225967, ENSG00000237599, ENSG00000223481, ENSG00000232326 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024339 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1529427-5] Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–73. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427.

[pmid1946428-6] Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A. 88 (22): 10094–8. Bibcode:1991PNAS...8810094B. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428.

[pmid16395595-7] Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet. 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595. S2CID 21059468.

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