TARS (gene)

TARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WWT, 4HWT, 4P3N, 4TTV
Identifiers
Aliases	TARS1, ThrRS, threonyl-tRNA synthetase, TARS, threonyl-tRNA synthetase 1, TTD7
External IDs	OMIM: 187790; MGI: 106314; HomoloGene: 11852; GeneCards: TARS1; OMA:TARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	33,468,091 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	11,399,751 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; islet of Langerhans; ; mucosa of transverse colon; ; gums; ; gingival epithelium; ; ventricular zone; ; buccal mucosa cell; ; epithelium of colon; ; oral cavity; ; cartilage tissue;
	Top expressed in
	primitive streak; ; epiblast; ; endothelial cell of lymphatic vessel; ; seminal vesicula; ; calvaria; ; hair follicle; ; left lobe of liver; ; genital tubercle; ; tail of embryo; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; protein binding; ATP binding; protein homodimerization activity; threonine-tRNA ligase activity; tRNA binding; RNA binding;
Cellular component	extracellular exosome; actin cytoskeleton; cytoplasm; cytosol;
Biological process	tRNA aminoacylation; tRNA aminoacylation for protein translation; protein biosynthesis; threonyl-tRNA aminoacylation;
	Sources:Amigo / QuickGO
Orthologs
	6897
	110960
	ENSG00000113407
	ENSMUSG00000022241
	P26639
	Q9D0R2
	NM_001258437; NM_001258438; NM_152295
	NM_033074
	NP_001245366; NP_001245367; NP_689508
	NP_149065
	Wikidata
View/Edit Human	View/Edit Mouse

Threonyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the TARS gene.^[5]

Aminoacyl tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113407 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022241 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: TARS threonyl-tRNA synthetase".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113407 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022241 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TARS threonyl-tRNA synthetase".

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