TATA-binding protein

TBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TGH, 1C9B, 1JFI, 1NVP, 4ROC, 4ROE, 4ROD, 5IY9, 5IYA, 5FUR, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	TBP, GTF2D, GTF2D1, HDL4, SCA17, TFIID, TATA-box binding protein, TATA-binding protein, TBP1
External IDs	OMIM: 600075; MGI: 101838; HomoloGene: 2404; GeneCards: TBP; OMA:TBP - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q27 Start 170,554,302 bp[1] End 170,572,870 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A2|17 8.95 cM Start 15,720,150 bp[2] End 15,748,641 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis oocyte gonad granulocyte sperm secondary oocyte mucosa of transverse colon middle temporal gyrus sural nerve Top expressed in tail of embryo spermatocyte zygote genital tubercle neural layer of retina secondary oocyte spermatid seminiferous tubule ventricular zone yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding enzyme binding TFIIB-class transcription factor binding aryl hydrocarbon receptor binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase III general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase III transcription regulatory region sequence-specific DNA binding Cellular component cytoplasm transcription factor TFIID complex male pronucleus female pronucleus nucleoplasm transcription factor TFIIA complex pronucleus nucleus transcription preinitiation complex protein-containing complex transcription factor TFIIIB complex transcription regulator complex Biological process termination of RNA polymerase I transcription epigenetic maintenance of chromatin in transcription-competent conformation regulation of transcription, DNA-templated transcription initiation from RNA polymerase I promoter transcription, DNA-templated positive regulation of transcription, DNA-templated spermatogenesis DNA-templated transcription, initiation transcription initiation from RNA polymerase II promoter snRNA transcription by RNA polymerase II regulation of signal transduction by p53 class mediator viral process regulation of transcription by RNA polymerase III transcription by RNA polymerase II transcription by RNA polymerase III RNA polymerase II preinitiation complex assembly regulation of transcription by RNA polymerase II RNA polymerase III preinitiation complex assembly transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6908 21374 Ensembl ENSG00000112592 ENSMUSG00000014767 UniProt P20226 P29037 RefSeq (mRNA) NM_003194 NM_001172085 NM_013684 RefSeq (protein) NP_001165556 NP_003185 NP_038712 Location (UCSC) Chr 6: 170.55 – 170.57 Mb Chr 17: 15.72 – 15.75 Mb PubMed search [3] [4]
Wikidata
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TBP
crystal structure of a yeast brf1-tbp-dna ternary complex
Identifiers
Symbol	TBP
Pfam	PF00352
Pfam clan	CL0407
InterPro	IPR000814
PROSITE	PDOC00303
SCOP2	1tbp / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The TATA-binding protein (TBP) is a general transcription factor that binds to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.^[5]