TCF/LEF family

Composite gene models of TCF/LEF genes. Extracted from Torres-Aguila et. al. (2022).[1]

The TCF/LEF family (T cell factor/lymphoid enhancer factor family) is a group of genes that encode transcription factors which bind to DNA through a SOX-like high mobility group domain. They are involved in the Wnt signaling pathway, particularly during embryonic [2] and stem-cell development,[3] but also had been found to play a role in cancer[4] and diabetes.[5] TCF/LEF factors recruit the coactivator beta-catenin to enhancer elements of genes they target. They can also recruit members of the Groucho family of corepressors.[6]

  1. ^ Torres-Aguila, Nuria P.; Salonna, Marika; Hoppler, Stefan; Ferrier, David E. K. (2022-02-03). "Evolutionary diversification of the canonical Wnt signaling effector TCF/LEF in chordates". Development, Growth & Differentiation. 64 (3): 120–137. doi:10.1111/dgd.12771. hdl:2164/18617. ISSN 0012-1592. PMC 9303524. PMID 35048372. S2CID 246161317.
  2. ^ Logan, Catriona Y.; Nusse, Roel (November 2004). "The WNT Signaling Pathway in Development and Disease". Annual Review of Cell and Developmental Biology. 20 (1): 781–810. doi:10.1146/annurev.cellbio.20.010403.113126. PMID 15473860.
  3. ^ Nusse, R (May 2008). "Wnt signaling and stem cell control". Cell Research. 18 (5): 523–7. doi:10.1038/cr.2008.47. PMID 18392048. S2CID 2503910.
  4. ^ Zhan, T; Rindtorff, N; Boutros, M (March 2017). "Wnt signaling in cancer". Oncogene. 36 (11): 1461–1473. doi:10.1038/onc.2016.304. PMC 5357762. PMID 27617575.
  5. ^ Laudes, M (April 2011). "Role of WNT signalling in the determination of human mesenchymal stem cells into preadipocytes". Journal of Molecular Endocrinology. 46 (2): R65-72. doi:10.1530/JME-10-0169. PMID 21247979.
  6. ^ Brantjes H, Barker N, van Es J, Clevers H (February 2002). "TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling". Biol. Chem. 383 (2): 255–61. doi:10.1515/BC.2002.027. PMID 11934263. S2CID 25665021.