TCF7

TCF7
Identifiers
Aliases	TCF7, TCF-1, transcription factor 7 (T-cell specific, HMG-box), transcription factor 7
External IDs	OMIM: 189908; MGI: 98507; HomoloGene: 135816; GeneCards: TCF7; OMA:TCF7 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	134,151,865 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	52,283,014 bp
RNA expression pattern
	Top expressed in
	thymus; ; periodontal fiber; ; lymph node; ; right uterine tube; ; granulocyte; ; cecum; ; appendix; ; blood; ; cardia; ; buccal mucosa cell;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; tail of embryo; ; zygote; ; blood; ; labioscrotal swelling; ; secondary oocyte; ; molar; ; epiblast; ; spleen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; beta-catenin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleus; nucleoplasm; nuclear body;
Biological process	cellular response to interleukin-4; regulation of transcription, DNA-templated; T cell receptor V(D)J recombination; negative regulation of transcription by RNA polymerase II; embryonic hindgut morphogenesis; Wnt signaling pathway; transcription, DNA-templated; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; embryonic genitalia morphogenesis; regulation of cell population proliferation; immune response; neural tube development; embryonic digestive tract morphogenesis; alpha-beta T cell differentiation; beta-catenin-TCF complex assembly; regulation of transcription by RNA polymerase II; canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6932
	21414
	ENSG00000081059
	ENSMUSG00000000782
	P36402
	Q00417
NM_001134851; NM_001134852; NM_003202; NM_201632; NM_201634;
	NM_213648; NM_001346425; NM_001346450; NM_001366502
	NM_009331; NM_001313981
NP_001128323; NP_001333354; NP_001333379; NP_003193; NP_963963;
	NP_963965; NP_998813; NP_001353431
	NP_001300910; NP_033357
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000081059 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000782 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000081059 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000782 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)".

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