TFAP2A

TFAP2A
Identifiers
Aliases	TFAP2A, AP-2, AP-2alpha, AP2TF, BOFS, TFAP2, transcription factor AP-2 alpha
External IDs	OMIM: 107580; MGI: 104671; HomoloGene: 2421; GeneCards: TFAP2A; OMA:TFAP2A - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p24.3 Start 10,393,186 bp[1] End 10,419,659 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A3.3|13 20.01 cM Start 40,868,778 bp[2] End 40,891,852 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh gingival epithelium skin of arm vulva skin of hip skin of abdomen hair follicle epithelium of lactiferous gland lactiferous duct nipple Top expressed in hair follicle epithelium of lens conjunctival fornix lip cornea lobe of prostate skin of abdomen parotid gland skin of external ear maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein dimerization activity protein homodimerization activity DNA-binding transcription factor activity transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding cis-regulatory region sequence-specific DNA binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding RNA polymerase II core promoter sequence-specific DNA binding sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component centrosome Golgi apparatus intracellular membrane-bounded organelle nucleus nucleoplasm cytosol Biological process roof of mouth development cellular response to iron ion regulation of transcription, DNA-templated retina layer formation kidney development positive regulation of bone mineralization trigeminal nerve development negative regulation of transcription by competitive promoter binding optic vesicle morphogenesis bone morphogenesis negative regulation of apoptotic process hearing eyelid development in camera-type eye transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of neuron apoptotic process positive regulation of gene expression inner ear morphogenesis optic cup structural organization regulation of cell differentiation embryonic cranial skeleton morphogenesis negative regulation of reactive oxygen species metabolic process negative regulation of transcription, DNA-templated embryonic forelimb morphogenesis oculomotor nerve formation negative regulation of cell population proliferation positive regulation of tooth mineralization transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7020 21418 Ensembl ENSG00000137203 ENSMUSG00000021359 UniProt P05549 P34056 RefSeq (mRNA) NM_001032280 NM_001042425 NM_003220 NM_001372066 NM_001122948 NM_001301674 NM_011547 RefSeq (protein) NP_001027451 NP_001035890 NP_003211 NP_001358995 NP_001116420 NP_001288603 NP_035677 Location (UCSC) Chr 6: 10.39 – 10.42 Mb Chr 13: 40.87 – 40.89 Mb PubMed search [3] [4]
Wikidata
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Transcription factor AP-2 alpha (Activating enhancer binding Protein 2 alpha), also known as TFAP2A, is a protein that in humans is encoded by the TFAP2A gene.^[5]