TFB2M

TFB2M
Identifiers
Aliases	TFB2M, Hkp1, mtTFB2, transcription factor B2, mitochondrial
External IDs	OMIM: 607055; MGI: 107937; HomoloGene: 7362; GeneCards: TFB2M; OMA:TFB2M - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	246,566,261 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	179,373,832 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; palpebral conjunctiva; ; right adrenal gland; ; right adrenal cortex; ; biceps brachii; ; tibia; ; left adrenal gland; ; right lobe of liver; ; parietal pleura; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	muscle of thigh; ; quadriceps femoris muscle; ; muscle tissue; ; skeletal muscle tissue; ; tail of embryo; ; zygote; ; renal cortex; ; proximal tubule; ; heart; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; transcription coregulator activity; rRNA methyltransferase activity; rRNA (adenine-N6,N6-)-dimethyltransferase activity; RNA binding;
Cellular component	cell junction; mitochondrial nucleoid; mitochondrial matrix; mitochondrion;
Biological process	positive regulation of transcription, DNA-templated; rRNA processing; methylation; mitochondrion organization; regulation of transcription, DNA-templated; rRNA methylation; transcription, DNA-templated; mitochondrial transcription; transcription initiation from mitochondrial promoter; rRNA modification;
	Sources:Amigo / QuickGO
Orthologs
	64216
	15278
	ENSG00000162851
	ENSMUSG00000026492
	Q9H5Q4
	Q3TL26
	NM_022366
	NM_008249; NM_001331054; NM_001331055
	NP_071761
	NP_001317983; NP_001317984; NP_032275
	Wikidata
View/Edit Human	View/Edit Mouse

Dimethyladenosine transferase 2; transcription factor B2, mitochondrial is an enzyme that in humans is encoded by the TFB2M gene.^[5]

This protein is a transcription initiation factor for the mitochondrial RNA polymerase, POLRMT. Its paralog TFB1M can perform a similar function, but only in vitro.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162851 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026492 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TFB2M transcription factor B2, mitochondrial".
^ Hillen, HS; Morozov, YI; Sarfallah, A; Temiakov, D; Cramer, P (16 November 2017). "Structural Basis of Mitochondrial Transcription Initiation". Cell. 171 (5): 1072–1081.e10. doi:10.1016/j.cell.2017.10.036. PMC 6590061. PMID 29149603.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162851 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026492 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TFB2M transcription factor B2, mitochondrial".

[polrmt-6] Hillen, HS; Morozov, YI; Sarfallah, A; Temiakov, D; Cramer, P (16 November 2017). "Structural Basis of Mitochondrial Transcription Initiation". Cell. 171 (5): 1072–1081.e10. doi:10.1016/j.cell.2017.10.036. PMC 6590061. PMID 29149603.

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