TFE3

TFE3
Identifiers
Aliases	TFE3, RCCP2, RCCX1, TFEA, bHLHe33, transcription factor binding to IGHM enhancer 3, MRXSPF
External IDs	OMIM: 314310; MGI: 98511; HomoloGene: 4755; GeneCards: TFE3; OMA:TFE3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	49,043,410 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	7,641,441 bp
RNA expression pattern
	Top expressed in
	inferior olivary nucleus; ; dorsal motor nucleus of vagus nerve; ; olfactory bulb; ; seminal vesicula; ; stromal cell of endometrium; ; secondary oocyte; ; left uterine tube; ; cartilage tissue; ; external globus pallidus; ; right adrenal cortex;
	Top expressed in
	zygote; ; granulocyte; ; secondary oocyte; ; primary oocyte; ; thin ascending limb of loop of Henle; ; molar; ; epiblast; ; cumulus cell; ; ankle; ; yolk sac;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; protein dimerization activity; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus; cytosol;
Biological process	positive regulation of cell adhesion; transcription, DNA-templated; transcription by RNA polymerase II; regulation of transcription, DNA-templated; adaptive immune response; regulation of osteoclast differentiation; immune system process; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; humoral immune response; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7030
	209446
	ENSG00000068323
	ENSMUSG00000000134
	P19532
	Q64092
	NM_001282142; NM_006521
NM_001105196; NM_001105197; NM_001271489; NM_001271490; NM_001271491;
	NM_172472
	NP_001269071; NP_006512
NP_001098666; NP_001098667; NP_001258418; NP_001258419; NP_001258420;
	NP_766060
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor E3 is a protein that in humans is encoded by the TFE3 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000068323 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000134 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puck JM, Stewart CC, Henthorn PS (May 1991). "A high-frequency RFLP at the human TFE3 locus on the X chromosome". Nucleic Acids Res. 19 (3): 684. doi:10.1093/nar/19.3.684-a. PMC 333678. PMID 1672758.
^ Henthorn PS, Stewart CC, Kadesch T, Puck JM (Feb 1992). "The gene encoding human TFE3, a transcription factor that binds the immunoglobulin heavy-chain enhancer, maps to Xp11.22". Genomics. 11 (2): 374–8. doi:10.1016/0888-7543(91)90145-5. PMID 1685140.
^ "Entrez Gene: TFE3 transcription factor binding to IGHM enhancer 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000068323 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000134 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1672758-5] Puck JM, Stewart CC, Henthorn PS (May 1991). "A high-frequency RFLP at the human TFE3 locus on the X chromosome". Nucleic Acids Res. 19 (3): 684. doi:10.1093/nar/19.3.684-a. PMC 333678. PMID 1672758.

[pmid1685140-6] Henthorn PS, Stewart CC, Kadesch T, Puck JM (Feb 1992). "The gene encoding human TFE3, a transcription factor that binds the immunoglobulin heavy-chain enhancer, maps to Xp11.22". Genomics. 11 (2): 374–8. doi:10.1016/0888-7543(91)90145-5. PMID 1685140.

[entrez-7] "Entrez Gene: TFE3 transcription factor binding to IGHM enhancer 3".

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