TGF alpha

TGFA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GK5, 1MOX, 1YUF, 1YUG, 2TGF, 3E50, 3TGF, 4TGF
Identifiers
Aliases	TGFA, TFGA, transforming growth factor alpha, Transforming growth factor - α
External IDs	OMIM: 190170; MGI: 98724; HomoloGene: 2431; GeneCards: TGFA; OMA:TGFA - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 70,447,284 bp[1] End 70,554,193 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 D1|6 37.62 cM Start 86,172,205 bp[2] End 86,252,701 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment skin of thigh pancreatic ductal cell islet of Langerhans amniotic fluid testicle epithelium of nasopharynx buccal mucosa cell nasal epithelium corpus callosum Top expressed in transitional epithelium of urinary bladder olfactory tubercle decidua lumbar subsegment of spinal cord vestibular membrane of cochlear duct lip nucleus accumbens belly cord globus pallidus suprachiasmatic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function epidermal growth factor receptor binding protein binding growth factor activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane plasma membrane integral component of plasma membrane extracellular region cell surface basolateral plasma membrane perinuclear region of cytoplasm ER to Golgi transport vesicle membrane endoplasmic reticulum-Golgi intermediate compartment membrane cytoplasmic vesicle Golgi membrane extracellular space clathrin-coated vesicle membrane Biological process positive regulation of epidermal growth factor-activated receptor activity positive regulation of epithelial cell proliferation endoplasmic reticulum to Golgi vesicle-mediated transport COPII vesicle coating cell population proliferation positive regulation of mitotic nuclear division positive regulation of cell division regulation of transcription by RNA polymerase II epidermal growth factor receptor signaling pathway positive regulation of cell population proliferation MAPK cascade signal transduction negative regulation of epidermal growth factor receptor signaling pathway positive regulation of protein kinase B signaling membrane organization intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7039 21802 Ensembl ENSG00000163235 ENSMUSG00000029999 UniProt P01135 P48030 RefSeq (mRNA) NM_001099691 NM_001308158 NM_001308159 NM_003236 NM_031199 RefSeq (protein) NP_001093161 NP_001295087 NP_001295088 NP_003227 NP_112476 NP_001390047 Location (UCSC) Chr 2: 70.45 – 70.55 Mb Chr 6: 86.17 – 86.25 Mb PubMed search [3] [4]
Wikidata
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Transforming growth factor alpha (TGF-α) is a protein that in humans is encoded by the TGFA gene.^[5] As a member of the epidermal growth factor (EGF) family, TGF-α is a mitogenic polypeptide.^[6] The protein becomes activated when binding to receptors capable of protein kinase activity for cellular signaling.

TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate.^[5]