TIK-301

TIK-301
Clinical data
Other names	Beta-methyl-6-chloromelatonin; LY-156735; PD-6735
Routes of; administration	Oral
Legal status
Legal status	Investigational;
Pharmacokinetic data
Elimination half-life	1 hour
Identifiers
	IUPAC name N-[(2R)-(6-Chloro-5-methoxy-1H-indol-3-yl)propyl]acetamide;
CAS Number	118702-11-7 ;
PubChem CID	219018;
IUPHAR/BPS	1351;
ChemSpider	189853 ;
UNII	3ZX95B1ZWK;
ChEMBL	ChEMBL4079759;
CompTox Dashboard (EPA)	DTXSID70922760 ;
Chemical and physical data
Formula	C14H17ClN2O2
Molar mass	280.75 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H](CNC(=O)C)c1c[nH]c2c1cc(c(c2)Cl)OC;
	InChI InChI=1S/C14H17ClN2O2/c1-8(6-16-9(2)18)11-7-17-13-5-12(15)14(19-3)4-10(11)13/h4-5,7-8,17H,6H2,1-3H3,(H,16,18)/t8-/m0/s1 ; Key:RKHCTAKUYDTFHE-QMMMGPOBSA-N ;
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TIK-301 (LY-156735) is an agonist for the melatonin receptors MT₁ and MT₂ that is under development for the treatment of insomnia and other sleep disorders.^[1] Its agonist action on MT₁ and MT₂ receptors in the suprachiasmatic nucleus in the brain enables its action as a chronobiotic. It is in the same class of melatonin receptor agonists as ramelteon and tasimelteon.

Clinical data

Other names	Beta-methyl-6-chloromelatonin; LY-156735; PD-6735
Routes of administration	Oral
Legal status
Legal status	Investigational
Pharmacokinetic data
Elimination half-life	1 hour
Identifiers
IUPAC name N-[(2R)-(6-Chloro-5-methoxy-1H-indol-3-yl)propyl]acetamide
CAS Number	118702-11-7^Y
PubChem CID	219018
IUPHAR/BPS	1351
ChemSpider	189853^N
UNII	3ZX95B1ZWK
ChEMBL	ChEMBL4079759
CompTox Dashboard (EPA)	DTXSID70922760
Chemical and physical data
Formula	C₁₄H₁₇ClN₂O₂
Molar mass	280.75 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@@H](CNC(=O)C)c1c[nH]c2c1cc(c(c2)Cl)OC
InChI InChI=1S/C14H17ClN2O2/c1-8(6-16-9(2)18)11-7-17-13-5-12(15)14(19-3)4-10(11)13/h4-5,7-8,17H,6H2,1-3H3,(H,16,18)/t8-/m0/s1^N Key:RKHCTAKUYDTFHE-QMMMGPOBSA-N^N
^NY (what is this?) (verify)