TIMD4

TIMD4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTIMD4, SMUCKLER, TIM4, T-cell immunoglobulin and mucin domain containing 4, T cell immunoglobulin and mucin domain containing 4
External IDsOMIM: 610096; MGI: 2445125; HomoloGene: 51381; GeneCards: TIMD4; OMA:TIMD4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146726
NM_138379

NM_178759

RefSeq (protein)

NP_001140198
NP_612388

NP_848874

Location (UCSC)Chr 5: 156.92 – 156.96 MbChr 11: 46.7 – 46.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene.[5] TIM-4 genes are in mouse present on chromosome 11B1.1 and in humans on chromosome 5q33.2. TIM-4 contains IgV domain with integrin-binding site as well as a unique metal-ion-dependent ligand binding site for phosphatidylserine.[6] TIM-4 also contains mucin domain with high levels of O-glycosylation. In comparison to other TIM proteins (such as TIM-1, TIM-2...) it does not contain a tyrosine-phosphorylation motif in its intracellular tail domain.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145850Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055546Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: T-cell immunoglobulin and mucin domain containing 4".
  6. ^ Santiago C, Ballesteros A, Martínez-Muñoz L, Mellado M, Kaplan GG, Freeman GJ, Casasnovas JM (December 2007). "Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds". Immunity. 27 (6): 941–51. doi:10.1016/j.immuni.2007.11.008. PMC 2330274. PMID 18083575.
  7. ^ Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK (August 2005). "The TIM gene family regulates autoimmune and allergic diseases". Trends in Molecular Medicine. 11 (8): 362–9. doi:10.1016/j.molmed.2005.06.008. PMID 16002337.