TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein with a molecular weight of 28 kDa.[5] TIMP1 is expressed from several tissues of organisms.
This protein is a member of the TIMP family. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000102265 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001131 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Nee, Larine E.; Mcmorrow, Tara; Campbell, Eric; Slattery, Craig; Ryan, Michael P. (2004-10-01). "TNF-α and IL-1β–mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells". Kidney International. 66 (4): 1376–1386. doi:10.1111/j.1523-1755.2004.00900.x. ISSN 0085-2538. PMID 15458430.