TLN1

TLN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SYQ, 2MWN, 4DJ9
Identifiers
Aliases	TLN1, ILWEQ, TLN, talin 1, talin-1
External IDs	OMIM: 186745; MGI: 1099832; HomoloGene: 21267; GeneCards: TLN1; OMA:TLN1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 35,696,948 bp[1] End 35,732,195 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 43,531,519 bp[2] End 43,562,691 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries ascending aorta right coronary artery Descending thoracic aorta left coronary artery muscle layer of sigmoid colon gastric mucosa body of uterus stromal cell of endometrium Top expressed in granulocyte stroma of bone marrow tibiofemoral joint ascending aorta superior surface of tongue gallbladder left lung external carotid artery aortic valve lymph node More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of cytoskeleton actin filament binding LIM domain binding integrin binding protein binding vinculin binding protein-containing complex binding actin binding cadherin binding phosphatidylserine binding phosphatidylinositol binding Cellular component cytoskeleton cell projection ruffle membrane ruffle cytosol extracellular exosome membrane cell surface cell-cell junction cell junction focal adhesion extracellular region cytoplasm plasma membrane Biological process cell-substrate junction assembly IRE1-mediated unfolded protein response muscle contraction platelet degranulation platelet aggregation cell-cell junction assembly cortical actin cytoskeleton organization cell adhesion viral process integrin-mediated signaling pathway integrin activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7094 21894 Ensembl ENSG00000137076 ENSMUSG00000028465 UniProt Q9Y490 P26039 RefSeq (mRNA) NM_006289 NM_011602 RefSeq (protein) NP_006280 NP_035732 Location (UCSC) Chr 9: 35.7 – 35.73 Mb Chr 4: 43.53 – 43.56 Mb PubMed search [3] [4]
Wikidata
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Talin-1 is a protein that in humans is encoded by the TLN1 gene.^[5][6] Talin-1 is ubiquitously expressed, and is localized to costamere structures in cardiac and skeletal muscle cells, and to focal adhesions in smooth muscle and non-muscle cells. Talin-1 functions to mediate cell-cell adhesion via the linkage of integrins to the actin cytoskeleton and in the activation of integrins. Altered expression of talin-1 has been observed in patients with heart failure, however no mutations in TLN1 have been linked with specific diseases.